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Regulation of feeding and therapeutic application of bioactive peptides
http://hdl.handle.net/10458/00010374
http://hdl.handle.net/10458/000103749575a720-f4b4-4a19-8218-15d3c80a91f1
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本文 (1.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2022-05-11 | |||||
| タイトル | ||||||
| タイトル | Regulation of feeding and therapeutic application of bioactive peptides | |||||
| 言語 | en | |||||
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| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Pancreatic acinar cell carcinoma | |||||
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| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Recurrence | |||||
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| 言語 | en | |||||
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| キーワード | Total pancreatectomy | |||||
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| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Neoadjuvant chemotherapy | |||||
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| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Case report | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
上野, 浩晶
× 上野, 浩晶× 中里, 雅光× Zhang, Weidong |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Obesity and obesity-related diseases, such as diabetes mellitus and dyslipidemia, are worldwide pandemics; therefore, studies have been conducted energetically to elucidate the mechanism of obesity and develop anti-obesity drugs. Robust progress in the peptide chemistry and molecular biology has identified many peptides that regulate appetite and energy metabolism over the past dozen years. Several drugs, such as analogs or receptor agonists of anorectic peptides, have been developed. Overall, peptide-related drugs have powerful anti-obesity effects with fewer adverse effects than previous anti-obesity drugs. Liraglutide, a glucagon-like peptide-1 receptor agonist, was first used as an antidiabetic drug, and then high-dose liraglutide was used as an anti-obesity drug. Several candidates have been developed to explore their anti-obesity effects. Additionally, hybrid peptides consisting of two or more peptide sequences with strong anorectic effects have been designed. Here, we review peptides that are important for feeding regulation in terms of their mechanisms of action, interactions, and clinical application as anti-obesity drugs. | |||||
| 書誌情報 |
en : Pharmacology & Therapeutics 巻 239, p. 108187, 発行日 2022 |
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 01637258 | |||||
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| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 35430293 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.pharmthera.2022.108187 | |||||
| 権利 | ||||||
| 権利情報 | © 2022 The Authors. Published by Elsevier Inc. | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 出版タイプ | VoR | |||||
