{"created":"2023-05-15T10:01:48.006384+00:00","id":6465,"links":{},"metadata":{"_buckets":{"deposit":"12ccf1cf-a46d-4d4a-8232-9b1feab69516"},"_deposit":{"created_by":5,"id":"6465","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"6465"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00006465","sets":["72","72:30"]},"author_link":["33797","34802","33796","33793","33799","21757","33795","33792","33798"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-02-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"170763","bibliographicVolumeNumber":"151","bibliographic_titles":[{"bibliographic_title":"Peptides","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ghrelin is a gastric-derived peptide that stimulates feeding, blood glucose elevation, body temperature reduction, and growth hormone （GH） secretion. Liver-expressed antimicrobial peptide 2 （LEAP2） is an endogenous antagonist of the ghrelin receptor, also called growth hormone secretagogue receptor （GHSR）. We studied the effects of LEAP2 administration on feeding, body weight, glycemia, body temperature, and inflammation-related genes in the liver in C57BL/6 J mice and Ghsr-knockout （Ghsr-KO） mice. We found that a single administration of LEAP2 did not abolish fasting-induced food intake in 24-h fasted C57BL/6 J mice or Ghsr-KO mice. Moreover, continuous LEAP2 administration to mice fed ad libitum for 6 days did not affect feeding, body temperature, plasma ghrelin, or blood glucose. By contrast, continuous LEAP2 administration to calorie-restricted C57BL/6 J mice and Ghsr-KO mice induced body weight loss, hypoglycemia, body temperature reduction, and upregulation of Il-6 and Il-1β mRNAs in the liver. Our findings suggest that LEAP2 functions independently of GHSR, implying that LEAP2 affects physiology beyond the ghrelin-GHSR system.","subitem_description_type":"Abstract"}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"35151767","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.peptides.2022.170763","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 The Author(s). Published by Elsevier Inc."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1873-5169","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Islam, Md Nurul","creatorNameLang":"en"},{"creatorName":"イスラム, エムディ　ヌルル　","creatorNameLang":"ja"},{"creatorName":"イスラム, 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Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"中里, 祐毅","creatorNameLang":"ja"},{"creatorName":"ナカザト, ユウキ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakazato, Yuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"中里","familyNameLang":"ja"},{"familyName":"ナカザト","familyNameLang":"ja-Kana"},{"familyName":"Nakazato","familyNameLang":"en"}],"givenNames":[{"givenName":"祐毅","givenNameLang":"ja"},{"givenName":"ユウキ","givenNameLang":"ja-Kana"},{"givenName":"Yuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33795","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90885972","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90885972"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Tanida, Ryota","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tanida","familyNameLang":"en"}],"givenNames":[{"givenName":"Ryota","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakoda, Hideyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takei, Toshiki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takao, Toshifumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33799","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"中里, 雅光","creatorNameLang":"ja"},{"creatorName":"ナカザト, マサミツ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakazato, 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MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://miyazaki-u.repo.nii.ac.jp/record/6465/files/1-s2.0-S0196978122000298-main.pdf"},"version_id":"2cc370a4-bd99-4006-8c91-4aa3eda1eef0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ghrelin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LEAP2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"JMV2959","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"[D-Lys3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"]-GHRP-6","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GHSR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anamorelin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Blood glucose","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Body temperature","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Liver-expressed antimicrobial peptide 2 functions independently of growth hormone secretagogue receptor in calorie-restricted mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Liver-expressed antimicrobial peptide 2 functions independently of growth hormone secretagogue receptor in calorie-restricted mice.","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-18"},"publish_date":"2022-03-18","publish_status":"0","recid":"6465","relation_version_is_last":true,"title":["Liver-expressed antimicrobial peptide 2 functions independently of growth hormone secretagogue receptor in calorie-restricted mice."],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2025-01-17T01:30:26.795525+00:00"}