{"created":"2023-05-15T11:10:41.402785+00:00","links":{},"metadata":{"_buckets":{"deposit":"dbb70434-3d8c-4f5e-8670-8c1f6df9d225"},"_deposit":{"id":"6465.1","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"6465.1"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00006465.1","sets":["72:30"]},"author_link":["33792","33793","33794","33795","33796","33797","33798","33799","21757"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-02-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"170763","bibliographicVolumeNumber":"151","bibliographic_titles":[{"bibliographic_title":"Peptides","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ghrelin is a gastric-derived peptide that stimulates feeding, blood glucose elevation, body temperature reduction, and growth hormone （GH） secretion. Liver-expressed antimicrobial peptide 2 （LEAP2） is an endogenous antagonist of the ghrelin receptor, also called growth hormone secretagogue receptor （GHSR）. We studied the effects of LEAP2 administration on feeding, body weight, glycemia, body temperature, and inflammation-related genes in the liver in C57BL/6 J mice and Ghsr-knockout （Ghsr-KO） mice. We found that a single administration of LEAP2 did not abolish fasting-induced food intake in 24-h fasted C57BL/6 J mice or Ghsr-KO mice. Moreover, continuous LEAP2 administration to mice fed ad libitum for 6 days did not affect feeding, body temperature, plasma ghrelin, or blood glucose. By contrast, continuous LEAP2 administration to calorie-restricted C57BL/6 J mice and Ghsr-KO mice induced body weight loss, hypoglycemia, body temperature reduction, and upregulation of Il-6 and Il-1β mRNAs in the liver. Our findings suggest that LEAP2 functions independently of GHSR, implying that LEAP2 affects physiology beyond the ghrelin-GHSR system.","subitem_description_type":"Abstract"}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"35151767","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.peptides.2022.170763","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 The Author(s). Published by Elsevier Inc."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1873-5169","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Islam, Md Nurul","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Weidong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakai, Katsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakazato, Yuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanida, Ryota","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakoda, Hideyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takei, Toshiki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takao, Toshifumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33799","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakazato, Masamitsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21757","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10180267","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10180267"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-18"}],"displaytype":"detail","filename":"1-s2.0-S0196978122000298-main.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://miyazaki-u.repo.nii.ac.jp/record/6465.1/files/1-s2.0-S0196978122000298-main.pdf"},"version_id":"6bf56878-3cbb-4fb3-82c3-f035cad31032"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ghrelin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LEAP2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"JMV2959","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"[D-Lys3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"]-GHRP-6","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GHSR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anamorelin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Blood glucose","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Body temperature","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Liver-expressed antimicrobial peptide 2 functions independently of growth hormone secretagogue receptor in calorie-restricted mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Liver-expressed antimicrobial peptide 2 functions independently of growth hormone secretagogue receptor in calorie-restricted mice.","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-18"},"publish_date":"2022-03-18","publish_status":"0","recid":"6465.1","relation_version_is_last":true,"title":["Liver-expressed antimicrobial peptide 2 functions independently of growth hormone secretagogue receptor in calorie-restricted mice."],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2025-06-01T23:44:28.545224+00:00"}