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アイテム
Dihydro-alpha-lipoic acid has more potent cytotoxicity than alpha-lipoic acid.
http://hdl.handle.net/10458/2512
http://hdl.handle.net/10458/2512205d6fbb-d7b4-482e-a980-bb31cd90d05c
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-02-16 | |||||
| タイトル | ||||||
| タイトル | Dihydro-alpha-lipoic acid has more potent cytotoxicity than alpha-lipoic acid. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| 著者 |
Masao, Yamasaki
× Masao, Yamasaki× Akiko, Kawabe× Kentaro, Nishimoto× Harishkumar, Madhyastha× Yoichi, Sakakibara× Masahito, Suiko× Takeaki, Okamoto× Taiji, Suda× Kenzo, Uehira× Kazuo, Nishiyama |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Alpha-lipoic acid has been shown to possess cancer-cell-killing activity via activation of the apoptosis pathway. In this study, the cytotoxic activities of alpha-lipoic and dihydro-alpha-lipoic acid were compared in HL-60 cells. The cell-killing activity of dihydro-alpha-lipoic acid was higher than that of alpha-lipoic acid. Both alpha-lipoic and dihydro-alpha-lipoic acid induced caspase-3 cleavage and internucleosomal DNA fragmentation in treated cells. On the other hand, apparent necrotic or late-stage apoptotic cell populations could be detected in dihydro-alpha-lipoic acid cells but not in those treated with alpha-lipoic acid. Moreover, dihydro-alpha-lipoic acid, but not alpha-lipoic acid, induced marked mitochondrial permeability transition. Antioxidants could not prevent dihydro-alpha-lipoic- or alpha-lipoic-acid-induced cell death. In addition, dihydro-alpha-lipoic and alpha-lipoic acid did not up-regulate cellular reactive oxygen level. These results indicated that dihydro-alpha-lipoic acid exerts more potent cytotoxicity than alpha-lipoic acid through different cytotoxic actions. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : In vitro cellular & developmental biology. Animal : journal of the Tissue Culture Association en : In vitro cell. dev. biol., Anim 巻 45, 号 5-6, p. 275-280, 発行日 2010-02-16 |
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| 出版者 | ||||||
| 出版者 | Tissue Culture Association | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 10712690 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1543706X | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11003480 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 19118438 | |||||
