{"created":"2023-05-15T10:01:18.599874+00:00","id":5839,"links":{},"metadata":{"_buckets":{"deposit":"0eb233c6-0ff9-4190-9b6d-e91f420efc77"},"_deposit":{"created_by":9,"id":"5839","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"5839"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00005839","sets":["76","76:63"]},"author_link":["31376"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-10-31"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"宮崎大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17601","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2018年度","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cell adhesion molecule 1 (CADM1), a member of the immunoglobulin superfamily, is identified as a novel cell surface marker for human T-cell leukemia virus (HTLV-1)-infected T cells. Adult T-cell leukemia/lymphoma (ATLL) is developed in HTLV-1-infected T-cells after a long infection period. To examine the mechanism of CADM1 overexpression in ATLL, we first identified that CADM1 is transcriptionally up-regulated by a transcriptional enhancer element through NF-????B signaling pathway. In HTLV-1-infected T-cells, CADM1 expression is dependent on HTLV-1/Tax through activation of canonical and non-canonical NF-????B; however, in ATLL cells with frequent loss of Tax expression, the activation of canonical NF-????B only enhances the CADM1 expression. Along with active mutations in signaling molecules under T-cell recepor (TCR) signaling, degradation of p47, a negative regulator of NF-????B, was essential for activation of canonical NF-????B through stabilization of NEMO (NF-????B essential modulator). The mechanism of p47 degradation is primarily dependent on activation of lysosomal-autophagy and the autophagy is activated in most of the HTLV-infected and ATLL cells, suggesting that the p47 degradation may be a first 3 key molecular event during HTLV-1 infection to T-cells as a connector of two important signaling pathways, NF-????B and autophagy.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"医獣医総博甲第83号"}]},"item_10006_textarea_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"本論文に関連する研究論文\nSarkar B, Nishikata I, Nakahata S, Ichikawa T, Shiraga T, Saha HR, Fujii M, Tanaka Y, Shimoda K, Morishita K. Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB. Sci Rep. 2019 Mar 5;9(1):3491. doi: 10.1038/s41598-019-39424-7. PMID: 30837480; PMCID: PMC6400899."}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sarkar, Bidhan Chandra","creatorNameLang":"en"},{"creatorName":"サルカル, ビードン チャンドラ","creatorNameLang":"ja"},{"creatorName":"サルカル, ビードン チャンドラ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Sarkar","familyNameLang":"en"},{"familyName":"サルカル","familyNameLang":"ja"},{"familyName":"サルカル","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Bidhan Chandra","givenNameLang":"en"},{"givenName":"ビードン チャンドラ","givenNameLang":"ja"},{"givenName":"ビードン チャンドラ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"31376","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"filename":"youshi.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"学位論文要旨","objectType":"abstract","url":"https://miyazaki-u.repo.nii.ac.jp/record/5839/files/youshi.pdf"},"version_id":"ab02d7f0-9e66-49ca-ae6b-2228c6aa7856"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"filename":"honbun.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"博士学位論文","objectType":"fulltext","url":"https://miyazaki-u.repo.nii.ac.jp/record/5839/files/honbun.pdf"},"version_id":"9289c427-6c91-4aa6-99b9-4f343fd7df24"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-01-24"}],"filename":"shinsa_kekka.pdf","filesize":[{"value":"675 KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"学位論文審査結果の要旨","objectType":"other","url":"https://miyazaki-u.repo.nii.ac.jp/record/5839/files/shinsa_kekka.pdf"},"version_id":"c03f7645-3d74-4940-b073-d5679a09c429"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB","subitem_title_language":"en"},{"subitem_title":"成人T細胞白血病リンパ腫における p47 発現低下は NF-κB の活性化を介して CADMI の高発現を誘導する","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"9","path":["76","63"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-21"},"publish_date":"2020-06-21","publish_status":"0","recid":"5839","relation_version_is_last":true,"title":["Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2024-02-09T08:09:06.520349+00:00"}