{"created":"2023-05-15T10:01:12.744861+00:00","id":5733,"links":{},"metadata":{"_buckets":{"deposit":"c614bc1c-3c95-495b-81d0-359034272e33"},"_deposit":{"created_by":5,"id":"5733","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"5733"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00005733","sets":["72","72:38"]},"author_link":["4839","23623"],"item_10010_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We report the ability of higher eukaryotes to gain un-programmed and new cell function（s） by means of irreversible creation of the chromatin structure plasticity through various generations. Following the exclusion of excessively accumulated IgM H- and L-chains in histone deacetylase-2 （HDAC2）-deficient DT40 mutants HDAC2（-/-） as a concrete case, we proposed a universal hypothetic concept on the ability of higher eukaryotic cells to adapt to abnormal and uncomfortable environment changes. When higher eukaryotic cells firstly encounter moderate intra- and/or extra-cellular environment change, they newly acquire ability to cope with and/or overcome it by means of irreversible creation of the varied chromatin structure plasticity surrounding proximal 5'-upstream regions of the specific transcription factor and chromatin-modifying enzyme genes with epigenetic modifications through various generations. Putative environment change recognition receptor/site （ECRR/ECRS） recognizes the new environment change. Putative chromatin conformation change complex （4C） machinery irreversibly and separately creates the varied chromatin structure plasticity of proximal 5'-upstream regions of the above-mentioned specific factor and enzyme genes in distinct ways in individual cells of the same type. We advance a chromatin conformation change code （4C） theory for a bio-system to gain un-programmed and new cell function（s） by means of irreversible creation of the chromatin structure plasticity by the 4C machinery through various generations, in order to adapt to the new environment change recognized by the ECRR/ECRS. The 4C theory is suitable as an explanation for the ways to control development and differentiation of higher eukaryotes.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10010_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The original edition of the revision is available from following URL: http://opac2.lib.miyazaki-u.ac.jp/webopac/TC10145263","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10010_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中山, 建男","creatorNameLang":"ja"},{"creatorName":"ナカヤマ, タツオ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakayama, Tatsuo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中山, 雅美","creatorNameLang":"ja"},{"creatorName":"ナカヤマ, マサミ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakayama, Masami","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"5_1_text_of_paper_5_revision.pdf","filesize":[{"value":"332.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"text","url":"https://miyazaki-u.repo.nii.ac.jp/record/5733/files/5_1_text_of_paper_5_revision.pdf"},"version_id":"38601677-15a6-4527-96e0-b2eae5a14a8c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-02-16"}],"displaytype":"detail","filename":"3-Text (3rd Edition) of 4C Theory.pdf","filesize":[{"value":"345.4 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cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"Chromatin conformation change code (4C) theory: A bio-system for gaining un-programmed and new cell functions by means of irreversible creation of chromatin structure plasticity with epigenetic modifications through various generations","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Chromatin conformation change code (4C) theory: A bio-system for gaining un-programmed and new cell functions by means of irreversible creation of chromatin structure plasticity with epigenetic modifications through various generations","subitem_title_language":"en"}]},"item_type_id":"10010","owner":"5","path":["72","38"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-21"},"publish_date":"2020-06-21","publish_status":"0","recid":"5733","relation_version_is_last":true,"title":["Chromatin conformation change code (4C) theory: A bio-system for gaining un-programmed and new cell functions by means of irreversible creation of chromatin structure plasticity with epigenetic modifications through various generations"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2024-01-30T04:26:05.942248+00:00"}