{"created":"2023-05-15T10:01:03.944336+00:00","id":5560,"links":{},"metadata":{"_buckets":{"deposit":"447d326f-73e2-4f81-b44e-1156fb54d1ae"},"_deposit":{"created_by":5,"id":"5560","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"5560"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00005560","sets":["80","80:65"]},"author_link":["29954","29955","29956","29957"],"item_10010_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-10","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"64","bibliographicPageStart":"62","bibliographic_titles":[{"bibliographic_title":"4th InternationalArsenic Symposium in MIYAZAKI 2015","bibliographic_titleLang":"en"}]}]},"item_10010_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although it is familiar that arsenic is ingested routinely by food substance such as seaweed,species of arsenic metabolite in urine are not fully identified. In order to assess the toxicity of arsenic contained in food properly, it is necessary to identify unknown arsenic metabolites. One of the efficient approaches is omics approach with high-performance liquid chromatography-electrospray ionisation tandem mass spectrometry （HPLC-ESI-MS/MS） using urine both before and after arsenic ingestion. However, analysis on arsenic species by LC-MS/MS is much less common than that by high performance liquid chromatography with inductively coupled plasma mass spectrometry （HPLC-ICP-MS）. Thus, analysis on available arsenic standard （i.e. arsenobetine, monomethyl arsonous acid, dimethylarsinic acid, trimethylarsine oxide, arsenocholine and dimethylmonothioarsinic acid） by HPLC-ESI-MS/MS was conducted as a pilot study. All of them without monomethyl arsonous acid was detected in a picogram or femtogram order. Furthermore, most of them can be quantitied at least in a picogram order. However, a part of them such as dimethylmonothioarsinic acid was completely undetected or little detected when they were added to urine sample even in a ppm order. Thus, it indicated the presence of an inhibitor for ionization in urine, and also did the necessity of sample preparation before analysis. However, extremely high sensitivity of arsenic metabolites suggested the possibility of omics approach.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10010_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"University of Miyazaki, IRISH","subitem_publisher_language":"en"}]},"item_10010_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamauch, Takenori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"29954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hata, Akihisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"29955","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamano, Yuko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"29956","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakadate, Toshio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"29957","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"s4-2_arsenic2015.pdf","filesize":[{"value":"249.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://miyazaki-u.repo.nii.ac.jp/record/5560/files/s4-2_arsenic2015.pdf"},"version_id":"52f0ff42-56dc-45e8-848b-d280f052b4b3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Arsenic, Metabolite, LC-MS/MS, Omics, Pilot study","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"Sensitive analysis of arsenic species in urine by LC-MS/MS","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sensitive analysis of arsenic species in urine by LC-MS/MS","subitem_title_language":"en"}]},"item_type_id":"10010","owner":"5","path":["80","65"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-21"},"publish_date":"2020-06-21","publish_status":"0","recid":"5560","relation_version_is_last":true,"title":["Sensitive analysis of arsenic species in urine by LC-MS/MS"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2023-07-30T04:37:16.608337+00:00"}