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DNA hypermethylation in arsenic-induced malignancies: a casuallink or a molecular paradigm
http://hdl.handle.net/10458/6263
http://hdl.handle.net/10458/6263600515ae-95a2-4324-8d26-e4edcff68223
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
本文 (201.3 kB)
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| Item type | その他 / Others(1) | |||||
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| 公開日 | 2020-06-21 | |||||
| タイトル | ||||||
| タイトル | DNA hypermethylation in arsenic-induced malignancies: a casuallink or a molecular paradigm | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Arsenic, DNA hypermethylation, turnor suppressor genes, epigenetic changes | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
| 資源タイプ | other | |||||
| 著者 |
Deekshit, VK
× Deekshit, VK× Anirban, Chakraborty× Madhyastha, Harish Kumar× lndrani, Karunasagar |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Arsenic is recognized as a toxicant and a poor mutagenic carcinogen. Non-occupational exposure to low or high concentrations of arsenic affects millions of people throughout the world including India. Although arsenic is a poor mutagen, it is known to cause various types of malignancies notably melanoma, oropharyngeal squamous cell carcinoma, cervical cancer, and esophageal cancer. Arsenic induced tumors show increased DNA methylation at the promoter regions of important tumor suppressor genes such as p16 and p53, suggesting an epigenetic mechanism of gene silencing in these kinds of tumors. The extent of DNA hypermethylation in such genes upon exposure to various levels of arsenic can be studied by performing simple methylation specific PCR using primers that can specifically target methylated DNA. Sequencing can also be done to validate the results of PCR. Further, the expression of p1 6 protein can be studied to confirm the results. The results obtained from the study would be helpful in early detection of DNA hypennethylation, which could be useful in predicting the risk of cancer in arsenic contaminated regions. In addition, studies on pharmacological reversal of DNA hypermethylation of tumor suppressor genes may offer therapeutic options to individuals exposed to arsenic. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : 4th InternationalArsenic Symposium in MIYAZAKI 2015 p. 32-33, 発行日 2015-10 |
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| 出版者 | ||||||
| 出版者 | University of Miyazaki, IRISH | |||||
| 言語 | en | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
