{"created":"2023-05-15T12:01:39.357143+00:00","links":{},"metadata":{"_buckets":{"deposit":"5a227810-4413-4a59-99c2-bf6b6a8e5951"},"_deposit":{"id":"5331.1","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5331.1"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00005331.1","sets":["76:63"]},"author_link":["28802","28805","28806","28807","7807","28809","28810","7804","7806"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"宮崎大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17601","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aims : Severe preterm fetal growth restriction (FGR) remote from term is problematic. We aimed to investigate the effect of maternally-administered antithrombin on maternal and neonatal outcomes. A prospective, one-arm, pilot study was performed in 14 women with severe FGR (≤5th centile) at <28 weeks of gestation, without hypertensive disorders. Maternal plasma concentrations of soluble Feline McDonough Sarcoma (FMS)-like trypsin kinase-1 (sFlt-1) and placental growth factor (PlGF) were measured and categorized into three groups: group 1; low sFlt-1 and high PlGF, group 2; moderate sFlt-1 and low PlGF, and group 3; high sFlt-1 and low PlGF. Antithrombin was administered for 3 days. The incidence of perinatal mortality, infant morbidity, and the period of pregnancy prolongation were compared.\n Results : In group 1 (n=4), their pregnancies were extended for longer periods and the maternal and infant outcomes were good. The prolongation periods were shorter in groups 2 (n=3) and 3 (n=7), which resulted in poor maternal [severe preeclampsia or hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome] and infant outcomes.\nConclusions : The evaluation of the maternal sFlt-1 and PlGF at 21–27 weeks of gestation is useful in the managements of severe FGR. Antithrombin treatment could prolong the pregnancies with low sFlt-1 and high PlGF without negatively affecting maternal or fetal health.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第52号"}]},"item_10006_publisher_5":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"wiley","subitem_publisher_language":"en"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"en","subitem_relation_name_text":"http://hdl.handle.net/10458/6180"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10458/6180","subitem_relation_type_select":"HDL"}}]},"item_10006_textarea_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_textarea_value":"以下に掲載:Journal of Perinatal Medicine .2017 ,Issue 7 , Volume45 , pp837-842, doi:https://doi.org/10.1515/jpm-2016-0190"},{"subitem_textarea_language":"ja"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤崎, 碧","creatorNameLang":"ja"},{"creatorName":"フジサキ, ミドリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"28802","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujisaki, Midori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"28805","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furuta, Ken","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"28806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohhashi, Masanao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"28807","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furukawa, Seishi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7807","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuki, Kodama","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"28809","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawagoe, Yasuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"28810","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sameshima, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7804","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50274775","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50274775"}]},{"creatorNames":[{"creatorName":"Ikenoue, Tsuyomu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7806","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"youshi.pdf","filesize":[{"value":"73.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"学位論文要旨 ","url":"https://miyazaki-u.repo.nii.ac.jp/record/5331.1/files/youshi.pdf"},"version_id":"1863c841-f8be-4db1-aa53-6c2e6555c054"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"shinsakekka.pdf","filesize":[{"value":"32.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"学位論文審査結果の要旨 ","url":"https://miyazaki-u.repo.nii.ac.jp/record/5331.1/files/shinsakekka.pdf"},"version_id":"ee477ae3-566d-450a-b9c8-cdf1bacf45c8"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"2017_fujisaki.pdf","filesize":[{"value":"295.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文 ","url":"https://miyazaki-u.repo.nii.ac.jp/record/5331.1/files/2017_fujisaki.pdf"},"version_id":"f4f44def-2bfc-43c7-bfeb-55d5e2391304"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Antithrombin, fetal growth restriction, perinatal mortality, placenta","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Antithrombin improves the maternal and neonatal outcomes but not the angiogenic factors in extremely growth-restricted fetuses at <28 weeks of gestation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antithrombin improves the maternal and neonatal outcomes but not the angiogenic factors in extremely growth-restricted fetuses at <28 weeks of gestation","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"2","path":["63"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-21"},"publish_date":"2020-06-21","publish_status":"0","recid":"5331.1","relation_version_is_last":true,"title":["Antithrombin improves the maternal and neonatal outcomes but not the angiogenic factors in extremely growth-restricted fetuses at <28 weeks of gestation"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-10-30T04:02:12.156105+00:00"}