@article{oai:miyazaki-u.repo.nii.ac.jp:00000471,
 author = {井上, 尚典 and Inoue, Naonori and 日高, 修二 and 三浦, 直良 and 山田, 耕太郎 and 深堀, 勝博 and Fukahori, Masahiro and Maruyama, Masugi and 丸山, 眞杉 and 河原, 聡 and Kawahara, Satoshi and 太田, 一良 and Ohta, Kazuyoshi and 六車, 三治男 and Muguruma, Michio and 井上, 尚典 and Inoue, Naonori and Hidaka, Shuji and Miura, Naoyoshi and Yamada, Kotaro and 深堀, 勝博 and Fukahori, Masahiro and Maruyama, Masugi and 丸山, 眞杉},
 issue = {1},
 journal = {YAKUGAKU ZASSHI, 薬学雑誌},
 month = {Jan},
 note = {Insulin resistance associated with visceral fat obesity has been suggested to be the pathological basis of metabolic syndrome. Many studies have demonstrated increased oxidant stress in diabetic patients and animal models of diabetes mellitus. In this study, the effect of liver hydrolysate administration on the blood glucose was examined in SHR/NDmcr-cp （SHR-cp） rats that show spontaneously occurring metabolic syndrome-like abnormalities. The SHR-cp rats were fed diets containing 5% liver hydrolysate for 12 weeks, and the fasting blood glucose and HbA1c were determined every 3 weeks. After administration of the liver hydrolysate-containing feed for 12 weeks, an oral glucose tolerance test was conducted and the plasma angiotensin II （AngII） concentrations were determined. The liver hydrolysate administration had no effect on the blood insulin levels in the oral glucose tolerance test, but significantly inhibited the d-glucose-induced increases of the blood glucose levels. Furthermore, the liver hydrolysate had almost no effect on the fasting blood glucose level, but tended to inhibit the increase of HbA1c. The plasma AngII concentration after the 12-week administration of liver hydrolysate remained significantly lower than that in the control group. These results indicate that a component of liver hydrolysate inhibits d-glucose-induced increase of the blood glucose level, and may improve insulin resistance. The angiotensin converting enzyme （ACE）-inhibiting effect and antioxidant effect of liver hydrolysate may be involved in this effect.},
 pages = {117--123},
 title = {メタボリックシンドロームモデルラット (SHR/NDmcr-cp) における肝臓水解物の血糖に及ぼす影響},
 volume = {133},
 year = {2013},
 yomi = {イノウエ, ナオノリ and ヒダカ, シュウジ and ミウラ, ナオヨシ and ヤマダ, コウタロウ and フカホリ, マサヒロ and マルヤマ, マスギ and カワハラ, サトシ and オオタ, カズヨシ and ムグルマ, ミチオ and イノウエ, ナオノリ and フカホリ, マサヒロ and マルヤマ, マスギ}
}