@article{oai:miyazaki-u.repo.nii.ac.jp:00004580,
 author = {本勝, 希実子 and Honsho, Kimiko and 廣瀬, 美智子 and Hirose, Michiko and Hatori, Masanori and Yasmin, Lubna and 伊豆, 美奈 and Izu, Haruna and 的場, 章悟 and Matoba, Shogo and Togayachi, Sumie and 三好, 浩之 and Miyoshi, Hiroyuki and 山海, 直 and Sankai, Tadashi and 小倉, 淳郎 and Ogura, Atsuo and Honda, Arata and 本多, 新},
 issue = {1},
 journal = {The Journal of reproduction and development},
 month = {Feb},
 note = {Quality evaluation of pluripotent stem cells using appropriate animal models needs to be improved for human regenerative medicine. Previously, we demonstrated that although the in vitro neural differentiating capacity of rabbit induced pluripotent stem cells （iPSCs） can be mitigated by improving their baseline level of pluripotency, i.e., by converting them into the so-called “naïve-like" state, the effect after such conversion of rabbit embryonic stem cells （ESCs） remains to be elucidated. Here we found that naïve-like conversion enhanced the differences in innate in vitro differentiation capacity between ESCs and iPSCs. Naïve-like rabbit ESCs exhibited several features indicating pluripotency, including the capacity for teratoma formation. They differentiated into mature oligodendrocytes much more effectively （3.3–7.2 times） than naïve-like iPSCs. This suggests an inherent variation in differentiation potential in vitro among PSC lines. When naïve-like ESCs were injected into preimplantation rabbit embryos, although they contributed efficiently to forming the inner cell mass of blastocysts, no chimeric pups were obtained. Thus, in vitro neural differentiation following naïve-like conversion is a promising option for determining the quality of PSCs without the need to demonstrate chimeric contribution. These results provide an opportunity to evaluate which pluripotent stem cells or treatments are best suited for therapeutic use., 本論文に関連する研究論文
Honsho K, Hirose M, Hatori M, Yasmin L, Izu H, Matoba S, Togayachi S, Miyoshi H, Sankai T, Ogura A, Honda A. Naïve-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells. J Reprod Dev. 2015;61(1):13-9. doi: 10.1262/jrd.2014-098. Epub 2014 Oct 25. PMID: 25345855; PMCID: PMC4354226.},
 pages = {13--19},
 title = {Naïve-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells},
 volume = {61},
 year = {2015},
 yomi = {ホンショウ, キミコ and ヒロセ, ミチコ and イズ, ハルナ and マトバ, ショウゴ and ミヨシ, ヒロユキ and サンカイ, タダシ and オグラ, アツオ and ホンダ, アラタ}
}