{"created":"2023-05-15T10:53:34.684616+00:00","links":{},"metadata":{"_buckets":{"deposit":"cb166c31-c3a0-4e72-ad56-42ccb7801090"},"_deposit":{"id":"3875.1","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"3875.1"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00003875.1","sets":["72:54"]},"author_link":["8181"],"item_10010_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-03","bibliographicIssueDateType":"Issued"}}]},"item_10010_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recently rat brain natriuretic peptide-45（rat BNP-45） was isolated from rat heart, and was shown to be a circulating form of rat BNP. We investigated the effects of rat BNP-45 in anesthetized spontaneously hypertensive rats （SHR） and Wistar-Kyoto rats （WKY）, and compared them with those of rat a-atrial natriuretic peptide（a-ANP）. BNP-45 was a potent natriuretic and hypotensive agent in both strains. The effects were comparable with those of a-ANP, and were far greater than those of porcine BNP-26 reported previously. In SHR blood pressure decreased more than in WKY following injection of the highest dose （2.0 nmol/kg） of BNP-45 or a-ANP. However, WKY was more susceptible than SHR to BNP-45 for diuresis, natriuresis and urinary cGMP excretion. Moreover, a high dose of BNP-45 led to prolonged lowering of blood pressure and urinary cGMP excretion compared to a-ANP, and those features were prominent in WKY. On the other hand, BNP-45 disappeared more slowly than a-ANP, when the two peptides （2.0μg） were injected intravenously in WKY. Thus, rat BNP-45 and a-ANP had comparable hypotensive and natriuretic potency. However, the action and plasma half-life of rat BNP-45 were more prolonged.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"北, 俊弘","creatorNameLang":"ja"},{"creatorName":"キタ, トシヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Kita, Toshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"kita1991.pdf","filesize":[{"value":"15.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kita1991.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/3875.1/files/kita1991.pdf"},"version_id":"9b6df87c-1803-40ce-9650-e7430f729fc6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"brain natriuretic peptide, atrial natriuretic peptide, blood pressure, natriuresis, metabolic clearance rate, rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"EFFECTS OF BRAIN NATRIURETIC PEPTIDE-45, A CIRCULATING FORM OF RAT BNP, IN SPONTANEOUSLY HYPERTENSIVE RATS","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"EFFECTS OF BRAIN NATRIURETIC PEPTIDE-45, A CIRCULATING FORM OF RAT BNP, IN SPONTANEOUSLY HYPERTENSIVE RATS","subitem_title_language":"en"},{"subitem_title":"実験高血圧ラットにおけるbrain natriuretic peptide(BNP)の血圧ならびに水・電解質代謝に及ぼす影響","subitem_title_language":"ja"}]},"item_type_id":"10010","owner":"2","path":["54"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-12-27"},"publish_date":"2012-12-27","publish_status":"0","recid":"3875.1","relation_version_is_last":true,"title":["EFFECTS OF BRAIN NATRIURETIC PEPTIDE-45, A CIRCULATING FORM OF RAT BNP, IN SPONTANEOUSLY HYPERTENSIVE RATS"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2024-01-30T04:19:48.903182+00:00"}