{"created":"2023-05-15T12:07:31.993760+00:00","links":{},"metadata":{"_buckets":{"deposit":"2009c2fa-ba78-4744-a37e-e8f64ac36ed4"},"_deposit":{"id":"3868.1","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"3868.1"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00003868.1","sets":["72:54"]},"author_link":["20915","20916"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-06-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"宮崎大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17601","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Abdominal aortic aneurysm (AAA) develops based on advanced atherosclerosis; however, the underlying pathogenesis remains unknown. Adrenomedullin (AM) is widely expressed in various human and rodent tissues, and has been reported to protect blood vessels. We have previously reported that AM is produced in mast cells of human AAA and that AM exhibited the antifibrotic activity of mast cell-derived AM on fibroblasts. In the present study, we investigated the role of AM in the development of AAA in 12-week-old male apolipoprotein (apo)E﹣/﹣ mice bred with AM heterozygous, or its role when recombinant human (rh) AM was administrated to the apoE﹣/﹣ male mice, which was infused with 1000 ng/kg/min of angiotensin II (Ang II) for 28 days. The incidence of the development of AAA in Ang II-infused apoE﹣/﹣ AM﹢/﹣ mice did not change compared with that in apoE﹣/﹣ mice (33.3% vs. 47.4%, p = 0.2333). In addition, rhAM administration had little effect on the incidence of the development of AAA formation (AM: 0 ng/kg/hr 47.4%; 300 ng/kg/hr 36.4%; 3000 ng/kg/hr 27.3%; p = 0.2595). In conclusion, this study suggests that AM does not contribute toward the development of AAA.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第421号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"en","subitem_relation_name_text":"http://creativecommons.org/licenses/by/4.0/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://creativecommons.org/licenses/by/4.0/","subitem_relation_type_select":"URI"}}]},"item_10006_relation_16":{"attribute_name":"他の資源との関係","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10458/4935"}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2014 by authors and Scientific Research Publishing Inc.","subitem_rights_language":"en"}]},"item_10006_textarea_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_textarea_value":"以下に掲載:Health. 2014, 6, 10, p.1077-1084, doi: 10.4236/health.2014.610133\nThis work is licensed under the Creative Commons Attribution International License (CC BY)."},{"subitem_textarea_language":"ja"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坂元, 紀陽","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Sumiharu","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"A421Yhakuron.pdf","filesize":[{"value":"54.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"A421Yhakuron.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/3868.1/files/A421Yhakuron.pdf"},"version_id":"ea44ba69-ec09-40ac-962a-3035a65f27d5"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"A421Yshinsa.pdf","filesize":[{"value":"62.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"A421Yshinsa.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/3868.1/files/A421Yshinsa.pdf"},"version_id":"ac26fe6f-17e9-45cd-a6a1-3945ffb76440"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"A421Honbun.pdf","filesize":[{"value":"614.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"A421Honbun.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/3868.1/files/A421Honbun.pdf"},"version_id":"6b0e1def-b678-4041-b3e6-809c788d7494"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Aneurysm, Angiotensin II, Aortic Rupture","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Adrenomedullin Does Not Contribute toward the Development of Abdominal Aortic Aneurysm in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Adrenomedullin Does Not Contribute toward the Development of Abdominal Aortic Aneurysm in Mice","subitem_title_language":"en"},{"subitem_title":"腹部大動脈瘤形成におけるアドレノメデュリンの役割","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"2","path":["54"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-08-01"},"publish_date":"2014-08-01","publish_status":"0","recid":"3868.1","relation_version_is_last":true,"title":["Adrenomedullin Does Not Contribute toward the Development of Abdominal Aortic Aneurysm in Mice"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2024-01-30T04:19:38.433879+00:00"}