@article{oai:miyazaki-u.repo.nii.ac.jp:00000372,
 author = {村上, 雄一 and Murakami, Yuichi and 立山, 晉 and Tateyama, Susumu and ランシピパット, アニュテープ and Rungsipipat, Anudep and 内田, 和幸 and Uchida, Kazuyuki and Yamaguchi, Ryoji and 山口, 良二 and 村上, 雄一 and Murakami, Yuichi and ランシピパット, アニュテープ and Rungsipipat, Anudep},
 issue = {7},
 journal = {The journal of veterinary medical science},
 month = {Jul},
 note = {The involvement of cyclin A, cyclin D1 and p53 proteins in canine and feline tumorigenesis was analyzed immunohistochemically. In the present study, a total of 176 cases were examined, among which there were 108 canine cases （75 mammary lesions, 16 squamous cell carcinomas and 17 basal cell tumors） and 68 feline cases （43 mammary lesions, 20 squamous cell carcinomas and 5 basal cell tumors）. Speckled nuclear staining for cyclin A was observed in 19/38 （50%） canine malignant mammary tumors and 18/37 （48.6%） feline mammary carcinomas, while this was not seen in benign mammary tumors of either dogs or cats. Marked intense nuclear cyclin A staining was seen in 7/16 （43.8%） canine squamous cell carcinomas and 18/20 （90.0%） feline squamous cell carcinomas. Only 3/17 （17.6%） canine basal cell tumors showed slight and scattered staining for cyclin A. Expression of cyclin D1 was very rare in both canine and feline tumors. Nuclear staining of p53 was found in 7/37 （18.9%） feline mammary carcinomas. Intense immunoreactivity for p53 was found in 6/16 （37.5%） canine squamous cell carcinomas and 8/20 （40%） feline squamous cell carcinomas. These results suggest that cyclin A may have a role in the proliferation of canine malignant mammary tumors, feline mammary carcinomas and squamous cell carcinomas of dogs and cats, and p53 may associate with the tumorigenesis of feline mammary carcinomas and squamous cell carcinomas of dogs and cats., Cyclin A・cyclin D1およびp53蛋白質の犬・猫腫瘍発生への関与について免疫組織化学的に解析した.本研究では176例を用い, 犬108例（乳腺75例・扁平上皮癌16例・基底細胞腫17例）・猫68例（乳腺43例・扁平上皮癌20例・基底細胞腫5例）であった.犬悪性乳腺腫瘍38例中19例（50%）・猫乳腺癌37例中18例（48.6%）でcyclin Aの染色性が核内に斑状に見られ, その良性腫瘍では見られなかった.また犬扁平上皮癌16例中7例（43.8%）・猫扁平上皮癌20例中18例（90.0%）でcyclin Aの著しく強い染色性が核内に見られた.犬基底細胞腫17例中3例（17.6%）のみがcyclin Aの軽度の染色性を核内に散在性に示した.Cyclin D1の発現は犬・猫腫瘍共に極めて稀であった.猫乳腺癌37例中7例（18.9%）でp53の染色性が核内に見られた.また犬扁平上皮癌16例中6例（37.5%）・猫扁平上皮癌20例中8例（40%）でp53の強い免疫反応性が見られた.これらの結果よりcyclin Aが犬悪性乳腺腫瘍・猫乳腺癌および犬・猫扁平上皮癌の増殖に関与すること, p53が猫乳腺癌および犬・猫扁平上皮癌の腫瘍発生に関与していることが示唆された.},
 pages = {743--750},
 title = {Immunohistochemical Analysis of Cyclin A, Cyclin D1 and P53 in Mammary Tumors, Squamous Cell Carcinomas and Basal Cell Tumors of Dogs and Cats},
 volume = {62},
 year = {2000},
 yomi = {ムラカミ, ユウイチ and タテヤマ, ススム and ランシピパット, アニュテープ and ウチダ, カズユキ and ヤマグチ, リョウジ and ムラカミ, ユウイチ and ランシピパット, アニュテープ}
}