@article{oai:miyazaki-u.repo.nii.ac.jp:00000367, author = {内田, 和幸 and Uchida, Kazuyuki and 村中, 美樹 and Muranaka, Miki and 村上, 隆之 and Murakami, Takayuki and Yamaguchi, Ryoji and 山口, 良二 and 立山, 晉 and Tateyama, Susumu and 村中, 美樹 and Muranaka, Miki}, issue = {12}, journal = {The journal of veterinary medical science}, month = {Dec}, note = {A gelatinous focus with cystic spaces, was found in the posterior funiculus of the 2nd to 3rd lumbar levels of the spinal cord of a Japanese Black heifer, 2 years old, with clinical signs of severe dysstasia. Histopathological examination revealed that the spinal lesion consisted of multifocal and diffuse proliferation of round cells with abundant vacuolar cytoplasm and hyperchromatic nuclei. In the lesions there was a number of cystic spaces containing aggregates of small round cells. The neoplastic foci showed a honeycomb structure divided by thin blood vessels, representing typical lesions of oligodendroglioma. Diffuse and multifocal proliferation of these round cells were also recognized in the subarachnoidal space in the sacral spinal cord. Immunohistochemically, the proliferating round cells were negative for glial fibrillary acidic protein. Based on these morphological features, the case was diagnosed as lumbar spinal oligodendroglioma with diffuse arachnoidal dissemination., 重度の運動失調を示した2歳,雌,黒毛和種牛の第2∼3腰椎部脊髄に嚢胞形成を伴うゼラチン状病巣が認められた.病理組織検索の結果同病巣では,豊富な空胞状の細胞質とクロマチンに富む核を有する円形細胞の多巣状性および瀰漫性増殖と小型円形細胞の集簇を含む多数の空胞病変が確認された.本病巣は,稀突起膠細胞腫に特徴的な蜂巣状構造を示し,薄い血管により区画されていた.また仙椎部脊髄の検索では,クモ膜下腔において瀰漫性ないし多巣状性の円形細胞増殖部が確認された.免疫組織化学的に,増殖性円形細胞はグリア線維性酸性蛋白(GFAP)に陰性を示した.以上の検索結果より,本例は瀰漫性クモ膜播種を伴う腰髄稀突起膠細胞腫を診断された.}, pages = {1323--1326}, title = {Spinal Oligodendroglioma with Diffuse Arachnoidal Dissemination in a Japanese Black Heifer}, volume = {61}, year = {1999}, yomi = {ウチダ, カズユキ and ムラナカ, ミキ and ムラカミ, タカユキ and ヤマグチ, リョウジ and タテヤマ, ススム and ムラナカ, ミキ} }