@article{oai:miyazaki-u.repo.nii.ac.jp:00000355,
 author = {Inoue, Yo and 村上, 昇 and Murakami, Noboru and 堀井, 洋一郎 and Horii, Yoichiro and Rivero, Juan C. and Inoue, Yo and Rivero, J.C.},
 issue = {6},
 journal = {The journal of veterinary medical science},
 month = {Jun},
 note = {The effects of male and female sex hormones on the protective capacity of Wistar rats against infection with Strongyloides venezuelensis were investigated. Male rats were more susceptible than females in terms of worm recovery from the lungs. Orchidectomy of male animals significantly reduced the plasma testosterone concentration and increased host resistance to the migratory stages of S. venezuelensis larvae. In contrast, ovariectomy of female animals significantly decreased host resistance in association with a significant reduction of estrogen levels. To examine the direct effect of sex hormones, exogenous testosterone and estrogen were implanted into animals. Susceptibility significantly increased or decreased in ovariectomized females given testosterone or estrogen, respectively. These results suggest that male and female sex hormones are important in the down- and up-regulation of host resistance against S. venezuelensis in Wistar rats., ウィスターラットにおいて,ベネズエラ糞線虫に対する感染抵抗能に及ぼす雄性ホルモンと雌性ホルモンの影響を調べた.虫体回収数による比較では,雄ラットは雌に比べて感染感受性が高く,雄の精巣除去により血中テストステロン濃度が減少し,体内移行期の糞線虫幼虫に対する感染抵抗性が著しく増大した.対照的に,雌ラットの卵巣除去により血中エストロゲン濃度の減少と相まって感染抵抗性が著しく減少した.性ホルモンの直接的な影響を見るために,外来性のテストステロンとエストロゲンを卵巣除去した雌ラットに移入したところ,テストステロンにより感染感受性の増大が,一方エストロゲンにより減少が見られた.これらの結果から,雄性ホルモンや雌性ホルモンはウィスターラットにおける,ベネズエラ糞線虫への抵抗性の抑制性あるいは増強性調節に重要な役割を持つことが示唆された.},
 pages = {457--461},
 title = {Androgen- and estrogen-dependent sex differences in host resistance to Strongyloides venezuelensis infection in Wistar rats},
 volume = {64},
 year = {2002},
 yomi = {井上, 陽 and イノウエ, ヨウ and ムラカミ, ノボル and ホリイ, ヨウイチロウ and 井上, 陽 and イノウエ, ヨウ}
}