@article{oai:miyazaki-u.repo.nii.ac.jp:00003314,
 author = {村上, 隆之 and Murakami, Takayuki and 萩尾, 光美 and Hagio, Mitsuyoshi and 那須, 哲夫 and Nasu, Tetsuo and 斎藤, 勇夫 and Saito, Isao},
 issue = {1},
 journal = {宮崎大学農学部研究報告, Bulletin of the Faculty of Agriculture, Miyazaki University},
 month = {Oct},
 note = {胎齢7か月～生後3歳のウシの正常な動脈管(DA)と動脈管開存症(PDA)のDA を組織学的に観察した.
 胎子のDA壁は内膜,中膜内層及び外層,外膜で構成され,連続した内弾性板は存在していたが,内膜クッションは存在しなかった.内膜クッションは生後に発育し,DA腔の全周を囲むのは4日齢以後であった. 59～121日齢で腔は内膜クッションによって閉塞し,その後,クッションは次第に壊死,消失した.内弾性板は腔が消失した後も連続性を維持し, 121日齢で部分的に断裂した.中膜内層の平滑筋線維は7～16日齢で変性を示した. その後, 平滑筋線椎は減少,膠原線維と弾性線維が次第に増加し,中腰内層は縮小した.中膜外層と外膜は年齢とともに膠原線維と弾性線維が増加したが,他に著明な変化は示さなかった.
 PDA の単独奇形2例及び大動脈の閉鎖性奇形に伴うPDA 8例のうち, 3日齢の2例のDA の組織構造は正常例と差がなかった. 5日齢以後の8例は内膜クッションの形成が不良であった.
 肺動脈の閉鎖性奇形に伴うPDA 3例では,中膜の形成が不良でDA 壁が薄かった. これら3例のうち, 2例は内膜クッションが形成不全であったが, 1例はクッションが充分に形成されていた.
 ウシのPDA のDA 壁に見られる連続した内弾性板は異常所見とは考えられなかった., The ductus arteriosus (DA) of normal hearts ranging from 7-month-old fetus to 3 years of age and 13 hearts with patent ductus arteriosus (PDA) in cattle were microscopically observed.
    The wall of the fetal DA consisted of an intima, inner and outer layers of the media, and an adventitia. The wall had a continuous internal elastic membrane and no intimal cushion. The intimal cushion developed after birth and enclosed the whole circumference of the DA lumen in specimens older than 4 days old. At between 59 and 121 days old, the lumen was occluded with the intimal cushion. After that the cushion necrosed and gradually obliterated. The continuity of the internal elastic lamina sustained after the obliteration of the lumen and focally disrupted at 121 days old. In the inner layer of the media, smooth muscle fibers showed degeneration at 7 to 16 days old. After that, the smooth muscle decreased and collagen and elastic fibers became more abundant, and the inner media gradually reduced. In the outer layer of the media and adventitia, collagen and elastic fibers increased with age, but no other significant changes occurred.
    In 2 isolated PDA and 8 PDA associated with obstructive anomalies of the aorta, two DA of 3 days old did not show any histological differences compared with the normal DA. Eight DA older than 5 days showed hpoplasia of their cushions.
    In 3 PDA associated with obstructive anomalies of the pulmonary artery, the thickness of the walls of DA was thin due to hypoplasia of their media. In 2 of these cases again showed hypoplasia of the intimal cushions, but the third case had a well developed cushion.
    The continuous internal elastic membrane in the wall of DA from the PDA cattle was not regarded as an abnormal picture.},
 pages = {123--130},
 title = {ウシの動脈管の組織学的構造},
 volume = {34},
 year = {1987}
}