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Comparative Metagenomics Revealed Commonly Enriched Gene Sets in Human Gut Microbiomes
http://hdl.handle.net/10458/4556
http://hdl.handle.net/10458/45563bd6fed3-1ab0-45fe-862a-7f917e4521e4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
hayasi_1976.pdf (838.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2013-07-12 | |||||
| タイトル | ||||||
| タイトル | Comparative Metagenomics Revealed Commonly Enriched Gene Sets in Human Gut Microbiomes | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | metagenomics, human gut microbiota, gene family, conjugative transposon | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
林, 哲也
× 林, 哲也× Kurokawa, Ken× Itoh, Takehiko× Kuwahara, Tomomi× Oshima, Kenshiro× Toh, Hidehiro× Toyoda, Atsushi× Takami, Hideto× Morita, Hidetoshi× Vineet, K. Sharma× Tulika, P. Srivastava× Todd, D. Taylor× Noguchi, Hideki× Mori, Hiroshi× Ogura, Yoshitoshi× Dusko, S. Ehrlich× Itoh, Kikuji× Takagi, Toshihisa× Sakaki, Yoshiyuki× 林, 哲也× Hattori, Masahira |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Numerous microbes inhabit the human intestine, many of which are uncharacterized or uncultivable. They form a complex microbial community that deeply affects human physiology. To identify the genomic features common to all human gut microbiomes as well as those variable among them, we performed a large-scale comparative metagenomic analysis of fecal samples from 13 healthy individuals of various ages, including unweaned infants. We found that, while the gut microbiota from unweaned infants were simple and showed a high inter-individual variation in taxonomic and gene composition, those from adults and weaned children were more complex but showed a high functional uniformity regardless of age or sex. In searching for the genes over-represented in gut microbiomes, we identified 237 gene families commonly enriched in adult-type and 136 families in infant-type microbiomes, with a small overlap. An analysis of their predicted functions revealed various strategies employed by each type of microbiota to adapt to its intestinal environment, suggesting that these gene sets encode the core functions of adult and infant-type gut microbiota. By analysing the orphan genes, 647 new gene families were identified to be exclusively present in human intestinal microbiomes. In addition, we discovered a conjugative transposon family explosively amplified in human gut microbiomes, which strongly suggests that the intestine is a `hot spot' for horizontal gene transfer between microbes. | |||||
| 書誌情報 |
DNA RESEARCH 巻 14, 号 4, p. 169-181, 発行日 2007-08 |
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| 出版者 | Oxford University Press | |||||
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13402838 | |||||
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| 出版タイプ | VoR | |||||
