{"created":"2023-05-15T09:56:39.396392+00:00","id":288,"links":{},"metadata":{"_buckets":{"deposit":"a5065074-a574-498e-9e5e-4b212ec95cab"},"_deposit":{"created_by":5,"id":"288","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"288"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00000288","sets":["74","74:26"]},"author_link":["1176","1319","939","937","940","1318"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-01-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"32","bibliographicPageStart":"27","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"The journal of veterinary medical science","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In order to evaluate the invo1vement of c-yes and c-erbB-2 oncogene products, and p53 tumor suppressor protein in canine mammary neoplastic lesions, sections of archived paraffin-embedded samp1es of 79 mammary tumors were analyzed immunohistochemically using antibodies against human c-yes p62 and c-erbB-2 products and p53. These 79 tumors were divided into 2 groups: 32 benign （2 adenosis, 7 simple adenomas, 14 complex adenomas, and 9 benign mixed mammary tumors） and 47 malignant tumors （26 simp1e adenocarcinomas, 7 complex adenocarcinomas, 5 solid carcinomas, 2 sclerosing carcinomas, 6 malignant mixed mammary tumors, and 1 malignant myoepithelioma）. As a resu1t of immunostaining, 40.6% （13/32） of the benign tumors and 21.3% （10/47） of the malignant tumors expressed the c-yes oncogene product, ErbB-2 expression was detected in 50% （16/32） of the benign tumors and in 19.1% （9/47） of the malignant tumors. P53 expression was detected in 16% （4/25） of the benign tumors and in 30.6% （11/36） of the malignant tumors. Co-expression of c-yes and ErbB-2, ErbB-2 and p53, and all 3 products was detected in 6, 1 and 7 tumors, respectively.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"イヌの乳腺腫瘍79例におけるc-yes, c-erbB-2およびp53の遺伝子産物の発現状況を知る目的で, それぞれの遺伝子産物に対する抗体を用いて免疫組織化学的に検討した. これらの乳腺腫瘍79例は組織学的に, 良性群32例（腺過形成2例, 単純型腺腫7例, 複合型腺腫14例, 良性混合腫瘍9例）と悪性群47例（単純型腺癌26例, 複合型腺癌7例, 充実型腺癌5例, 硬化癌2例, 悪性混合腫瘍6例, 悪性筋上皮腫1例）に分類された. 免疫染色の結果, c-Yesは良性群の40.6%（32例中13例）, 悪性群の21.3%（47例中10例）に発現が認められ, またErbB-2は良性群の50%（32例中16例）, 悪性群の19.1%（47例中9例）で陽性像が観察された. これに対してp53は, 良性群の16%（25例中4例）, 悪性群の30.6%（36例中11例）で陽性像が確認された. また, 検索例中, c-YcsとErbB-2, ErbB-2とp53, および3種すべての共発現が6例, 1例, 7例にそれぞれ認められた.","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Society of Veterinary Science","subitem_publisher_language":"en"},{"subitem_publisher":"日本獣医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_18":{"attribute_name":"他の資源との関係","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://ci.nii.ac.jp/naid/110003920029/"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本獣医学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである","subitem_rights_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10796138","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09167250","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"ランシピパット, アニュテープ","creatorNameLang":"ja"},{"creatorName":"ランシピパット, アニュテープ","creatorNameLang":"ja-Kana"},{"creatorName":"Rungsipipat, Anudep","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"立山, 晉","creatorNameLang":"ja"},{"creatorName":"タテヤマ, ススム","creatorNameLang":"ja-Kana"},{"creatorName":"Tateyama, Susumu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Yamaguchi, Ryoji","creatorNameLang":"en"},{"creatorName":"山口, 良二","creatorNameLang":"ja"},{"creatorName":"ヤマグチ, リョウジ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"内田, 和幸","creatorNameLang":"ja"},{"creatorName":"ウチダ, カズユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Uchida, Kazuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"三好, 宣彰","creatorNameLang":"ja"},{"creatorName":"ミヨシ, ノリアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyoshi, Noriaki","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"林, 俊春","creatorNameLang":"ja"},{"creatorName":"ハヤシ, トシハル","creatorNameLang":"ja-Kana"},{"creatorName":"Hayashi, Toshiharu","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"ランシピパット, アニュテープ","creatorNameLang":"ja"},{"creatorName":"ランシピパット, アニュテープ","creatorNameLang":"ja-Kana"},{"creatorName":"Rungsipipat, Anudep","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"三好, 宣彰","creatorNameLang":"ja"},{"creatorName":"ミヨシ, ノリアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyoshi, Noriaki","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"林, 俊春","creatorNameLang":"ja"},{"creatorName":"ハヤシ, トシハル","creatorNameLang":"ja-Kana"},{"creatorName":"Hayashi, Toshiharu","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"jvms61-1_27.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JVMS61(1)27.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/288/files/jvms61-1_27.pdf"},"version_id":"daf5243c-8e63-4943-8bba-e96a72e82661"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"canine, mammary tumor, oncogene","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Immunohistochemical Analysis of c-yes and c-erbB-2 Oncogene Products and p53 Tumor Suppressor Protein in Canine Mammary Tumors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunohistochemical Analysis of c-yes and c-erbB-2 Oncogene Products and p53 Tumor Suppressor Protein in Canine Mammary Tumors","subitem_title_language":"en"},{"subitem_title":"イヌの乳腺腫瘍におけるc-yesおよびc-erbB-2癌遺伝子産物, およびp53癌抑制蛋白の発現に関する免疫組織化学的検索","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"5","path":["74","26"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-02-08"},"publish_date":"2008-02-08","publish_status":"0","recid":"288","relation_version_is_last":true,"title":["Immunohistochemical Analysis of c-yes and c-erbB-2 Oncogene Products and p53 Tumor Suppressor Protein in Canine Mammary Tumors"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2023-10-23T02:25:38.000969+00:00"}