@article{oai:miyazaki-u.repo.nii.ac.jp:00000283, author = {立山, 晉 and Tateyama, Susumu and 三好, 宣彰 and Miyoshi, Noriaki and 内田, 和幸 and Uchida, Kazuyuki and Yamaguchi, Ryoji and 山口, 良二 and 大塚, 宏光 and Mina, Rostami B. and Mina, Rostami and 三好, 宣彰 and Miyoshi, Noriaki and Ohtsuka, Hiromitsu and Mina, Rostami B. and Mina, Rostami}, issue = {4}, journal = {The journal of veterinary medical science}, month = {Aug}, note = {Genomic DNAs from 4 canine spontaneous lymphoid neoplasms were examined by Southern blot hybridization using 7kinds of oncogene probes. Analysis using a human c-yes-1 cDNA probe revealed amplification of the proto-oncogene in a DNA sample from a dog with lymphoid leukemia. Its degree was about 4- to 8- fold in comparison with a control DNA sample from a healthy dog. The genomic abrlormality of canine c-yes-1-related oncogene may have a role in the tumorigenesis of this neoplasm, although the significance of the structural change in this oncogene remains unclear., イヌリンパ系腫瘍4例のゲノムDNAを, 7種ガン遺伝子プローブを用いたサザンブロットハイブリダイゼイションにより検索した. イヌリンパ性白血病症例において, ヒトc-yes-1関連イヌガン遺伝子に4~8倍の遺伝子増幅が検出された. この遺伝子増幅の意義については不明であるが, 本腫瘍の発生に何らかの関連があるのではないかと思われた.}, pages = {773--774}, title = {Amplification of a c-yes-1-Related Oncogene in Canine Lymphoid Leukemia}, volume = {56}, year = {1994}, yomi = {タテヤマ, ススム and ミヨシ, ノリアキ and ウチダ, カズユキ and ヤマグチ, リョウジ and オオツカ, ヒロミツ and ミヨシ, ノリアキ} }