@article{oai:miyazaki-u.repo.nii.ac.jp:00000277,
 author = {内田, 和幸 and Uchida, Kazuyuki and 奥田, 龍太郎 and Yamaguchi, Ryoji and 山口, 良二 and 立山, 晉 and Tateyama, Susumu and 中山, 裕之 and Nakayama, Hiroyuki and 後藤, 直彰 and Okuda, Ryutaro and 中山, 裕之 and Nakayama, Hiroyuki and Goto, Naoaki},
 issue = {4},
 journal = {The journal of veterinary medical science},
 month = {Aug},
 note = {The relationship of senile plaques to neuronal cells, neurites, glial cells, or capillaries was examined using double labeling-immunostaining methods on the Bouin's solution-fixed serial brain sections from dogs. Compact deposits of beta protein （amyloid plaques） in the cerebral cortex always contained microvessels labeled by anti-collagen type IV antibody and some of them might be formed as the result of fusion of several perivascular beta amyloid deposits. In the periphery of those plaques swollen neurites recognized with anti-neurofilament antibody were sometimes present, but the relation between such plaques and neuronal cells or glial cells were unclear. Diffuse deposition of beta protein （diffuse plaques） was frequently developed beside neuronal cells, while most plaques did not contain glial cells. Some of those plaques were closely contact with microvessels, but some had no relation. Intact or irregularly arranged neurites were present in diffuse plaques. Such irregularity of the neurites were obvious in the plaques in the hippocampus as compared with those in the cerebral cortex. These results indicate the possibility that canine amyloid plaques would be formed as the result of amyloid degeneration of cortical capillaries, and diffuse parenchymal deposition of beta protein would originate from neuronal or neurotic processes., イヌの老人斑と神経細胞, 神経突起, 神経膠細胞, 及び毛細血管との関係について, ブアン固定した大脳の連続パラフィン切片を用い二重免疫染色により検討した. amyloid plaqueは常に毛細血管を含んでおり, しばしば数本の毛細血管周囲に沈着したβ蛋白が融合し老人斑様の構造を形成する像が認められた. これらの老人斑の周囲には腫脹した神経突起が稀に認められた. なお, amyloid plaqueと神経細胞及び膠細胞との関連は不明瞭であった. 一方diffuse plaqueは頻繁に神経細胞の周囲に形成されていた. また正常あるいは不規則に配列する神経突起がdiffuse plaque内やその周囲に認められ, 特に海馬にdiffuse plaqueが認められた症例の海馬で明瞭に確認された. なおdiffuse plaqueと毛細血管及び膠細胞との関係は不明瞭であった. 以上の観察結果より, イヌのamyloid plaqueは毛細血管のアミロイド変性に関連して形成され, 一方diffuse plaque形成には神経細胞と神経突起の役割が重要である事が示唆された.},
 pages = {642--637},
 title = {Double-Labeling Immunohistochemical Studies on Canine Senile Plaques and Cerebral Amyloid Angiopathy},
 volume = {55},
 year = {1993},
 yomi = {ウチダ, カズユキ and オクダ, リョウタロウ and ヤマグチ, リョウジ and タテヤマ, ススム and ナカヤマ, ヒロユキ and ゴトウ, ナオアキ and ナカヤマ, ヒロユキ}
}