@article{oai:miyazaki-u.repo.nii.ac.jp:00000273, author = {趙, 徳明 and Yamaguchi, Ryoji and 山口, 良二 and 立山, 晉 and Tateyama, Susumu and 山崎, ゆみ and Yamazaki, Yumi and 小川, 博之 and Zhao, Deming and 山崎, ゆみ and Yamazaki, Yumi and Ogawa, Hiroyuki}, issue = {4}, journal = {The journal of veterinary medical science}, month = {Aug}, note = {A lymphosarcoma originating from kidneys, which metastasized to the ovaries, oviducts, heart and pancreas, was pathologically diagnosed in a 3-year-old female Japanese dog (Shiba dog). Clinically, the dog exhibited vomiting, diarrhea, oliguria and abdominal enlargement, associated with hypoglycemia. Grossly, the kidneys were enlarged and neoplastic masses were also seen in the ovaries and heart. Histologically, a majority of glomeruli and renal tubules were obliterated due to diffuse invasion by tumor cells. There were no metastatic lesions in the mesenteric and tracheobronchial lymph nodes, spleen and bone marrow. Most of the tumor cells were small- to medium- sized lymphoid cells with a large nucleus and scanty cytoplasm., 3歳の雌柴犬に腎臓原発のリンパ肉腫を認めた. 剖検では, 腎臓は黄色調を示して著しく腫大し, 膵臓, 心臓, 卵巣, 輸卵管, 消化管に腫瘍の転移巣が認められた. 組織学的には, 腎臓の皮質, 髄質両者に腫瘍細胞が瀰慢性に増殖し, 糸球体は萎縮し, ほとんどの尿細管は壊死・消失していた. 腫瘍細胞は小型~中型で, 細胞質に乏しく, 核は円形でクロマチンに富んでいた. 腸間膜, 気管支その他のリンパ節, 脾臓, 骨髄などには著変は認められなかった.}, pages = {657--659}, title = {Bilateral Renal Lymphosarcoma in a Dog}, volume = {55}, year = {1993}, yomi = {ヤマグチ, リョウジ and タテヤマ, ススム and ヤマザキ, ユミ and オガワ, ヒロユキ and ヤマザキ, ユミ} }