{"created":"2023-05-15T09:56:38.378707+00:00","id":269,"links":{},"metadata":{"_buckets":{"deposit":"e9bdf4a9-4e52-46ef-874d-3188e7d4fd67"},"_deposit":{"created_by":5,"id":"269","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"269"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00000269","sets":["74","74:26"]},"author_link":["1104","1071","1102","1100","1107","1081","1099","1105"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"760","bibliographicPageStart":"751","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"The journal of veterinary medical science","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A serious symptom of cattle affected with Chediak-Higashi syndrome （CHS） is a bleeding tendency. This diathesis is characterized by insufficient platelet aggregation as a result of depressed response to collagen. One possible cause for the depression is a decrease in contribution of endogenous agonists such as ADP or thromboxane A2, which are released following collagen stimulation. However, these endogenous agonists play only a minor role in collagen-induced aggregation of bovine platelets. More importantly, activation of phospholipase C as a result of a direct action of collagen is depressed, leading to a depression of Ca2+ mobilization, in platelets from CHS-affected cattle. Several types of collagen receptor are proposed to work in concert to induce aggregation. Among them, glycoprotein VI （GPVI） and GPIa/IIa （integrin α2β1） have been supposed to play dominant roles in collagen-induced aggregation. However, there are arguments about the role of each receptor, especially the role of GPIa/IIa, and the crosstalk between receptors. Recently, we reported that the Ca2+ signaling produced by rhodocytin, which had been first reported to be an agonist for the collagen receptor GPIa/ IIa, produced much less Ca2+ signaling in CHS platelets than in normal ones, whereas that produced by GPVI activators was normal. These suggest that GPIa/IIa or the rhodocytin-associated pathway is impaired in CHS platelets. CHS platelets are valuable to reassess the mechanism of collagen-dependent signal transduction system and to delineate the inter-relationship among collagen receptors, Platelet.\n\\n人、牛、マウス、ミンク等で認められるチェディアック・東症候群（CHS）の牛における重大な症状は出血傾向であり、それはコラーゲンに対する反応低下による血小板凝集不全に起因する。凝集不全の原因としてコラーゲン刺激によって生じるADPやトロンポキサンA2などの内因性アゴニストの関与が低下していることが考えられる。しかし、内因性アゴニスト阻害薬を用いた実験から、牛血小板のコラーゲン凝集においてこれら2次性アゴニストの役割は小さく、反応低下の主要な原因はむしろコラーゲンによるホスホリパーゼC活性化の抑制であり、そのためCa2+動員が抑制されていると考えられる。コラーゲンレセプターは数種類存在し、これらが共同して凝集を起こすが、そのシグナル伝達機構については不明な点も多い。当初、コラーゲンレセプターのひとつであるGPla/lla（インテグリンα2β1）のアゴニストであると報告されたRhodocytinは、CHS血小板ではきわめて抑制された反応を起こした。Rhodocytinの作用部位はいまだ確定していないが、rhodocytinに感受性のある機構が欠損していることがCHS血小板の機能異常に関与していることが示唆される。CHS決勝版は複雑なコラーゲンレセプターの相互関係を解明するのに有用である。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Society of Veterinary Science","subitem_publisher_language":"en"},{"subitem_publisher":"日本獣医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_18":{"attribute_name":"他の資源との関係","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://ci.nii.ac.jp/naid/110003920935"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本獣医学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである","subitem_rights_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10796138","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09167250","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"白石, 光也","creatorNameLang":"ja"},{"creatorName":"シライシ, ミツヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小川, 博之","creatorNameLang":"ja"},{"creatorName":"オガワ, ヒロユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"池田, 正浩","creatorNameLang":"ja"},{"creatorName":"イケダ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikeda, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"川島, 幸子","creatorNameLang":"ja"},{"creatorName":"カワシマ, サチコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"伊藤, 勝昭","creatorNameLang":"ja"},{"creatorName":"イトウ, カツアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Katsuaki","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiraishi, Mitsuya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogawa, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawashima, Sachiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"伊藤, 勝昭","creatorNameLang":"ja"},{"creatorName":"イトウ, カツアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Katsuaki","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"jvms64-9-751.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JVMS64(9)751.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/269/files/jvms64-9-751.pdf"},"version_id":"d909eb3a-5058-42cd-b9a2-0a53a498e614"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ca2+ signaling, cattle, Chediak-Higashi syndrome, Collagen receptor, Platelet","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Platelet Dysfunction in Chediak-Higashi Syndrome-Affected Cattle","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Platelet Dysfunction in Chediak-Higashi Syndrome-Affected Cattle","subitem_title_language":"en"},{"subitem_title":"チェディアック・東症候群の牛における血小板機能異常","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"5","path":["74","26"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-02-01"},"publish_date":"2008-02-01","publish_status":"0","recid":"269","relation_version_is_last":true,"title":["Platelet Dysfunction in Chediak-Higashi Syndrome-Affected Cattle"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2023-10-10T05:50:20.972190+00:00"}