{"created":"2023-05-15T10:36:39.832749+00:00","links":{},"metadata":{"_buckets":{"deposit":"77c78ffd-50eb-40ec-96cc-ac7f7acb2ed4"},"_deposit":{"id":"260.1","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"260.1"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00000260.1","sets":["74:26"]},"author_link":["1009","937","939","940","1013"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-08-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"912","bibliographicPageStart":"909","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"The journal of veterinary medical science","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The expression of cyctins A, D1, D2 and E were examined immunohistochemically in 5 canine normal testes and 31 testicular tumors, including 14 seminomas, 11 Sertoli cell tumors and 6 Leydig cell tumors. In canine normal testes, cyclin A expression was detected in spermatogonia and primary spermatocytes. This suggests that A-type cyclins may play some role in canine spermatogenesis. Cyclin A expression was also observed in 13/14 （92.9%） seminomas and 2/11 （18.2%） Sertoli cell tumors, but no positive reaction was observed in Leydig cell tumors. Parallel examinations for cyclins D1, D2 and E gave negative results in canine normal testes and testicular tumors. High levels of cyclin A expression in canine seminomas indicate that the neoplastic germ cells may be arrested at the spermatogonia and primary spermatocyte stages of differentiation.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"犬の正常精巣5例および精巣腫瘍31例（精細胞腫14例・セルトリ細胞腫11例・間細胞腫6例）におけるcyclin A・D1・D2およびEの発現を免疫組織化学的に検索した. 正常精巣では, cyclin Aの発現が精祖細胞および精母細胞で検出され, Aタイプのcyclinが精子形成に関与することが示唆された. また, 精細胞腫の14例中13例（92.9%）およびセルトリ細胞腫の11例中2例（18.2%）でcyclin Aの発現がみられたが, 間細胞腫にはみられなかった. 他のcyclinは, 正常精巣, 精巣腫瘍ともに陰性であった. 精細胞腫における高レベルのcyclin Aの発現は, その腫瘍細胞が精祖細胞および精母細胞の分化段階にあることを示している.","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Society of Veterinary Science","subitem_publisher_language":"en"},{"subitem_publisher":"日本獣医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_18":{"attribute_name":"他の資源との関係","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://ci.nii.ac.jp/naid/110003920715/"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本獣医学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである","subitem_rights_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10796138","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09167250","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"村上, 雄一","creatorNameLang":"ja"},{"creatorName":"ムラカミ, ユウイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"立山, 晉","creatorNameLang":"ja"},{"creatorName":"タテヤマ, ススム","creatorNameLang":"ja-Kana"},{"creatorName":"Tateyama, Susumu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"内田, 和幸","creatorNameLang":"ja"},{"creatorName":"ウチダ, カズユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Uchida, Kazuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山口, 良二","creatorNameLang":"ja"},{"creatorName":"ヤマグチ, リョウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Murakami, Yuichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"jvms63-8-909.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JVMS63(8)909.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/260.1/files/jvms63-8-909.pdf"},"version_id":"a750cf53-2f59-4d6f-98a2-46598a15a961"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"canine, cyclin, seminoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Immunohistochemical Analysis of Cyclins in Canine Normal Testes and Testicular Tumors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunohistochemical Analysis of Cyclins in Canine Normal Testes and Testicular Tumors","subitem_title_language":"en"},{"subitem_title":"犬の正常精巣および精巣腫瘍におけるcyclinの免疫組織化学的解析","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"2","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-02-08"},"publish_date":"2008-02-08","publish_status":"0","recid":"260.1","relation_version_is_last":true,"title":["Immunohistochemical Analysis of Cyclins in Canine Normal Testes and Testicular Tumors"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-07-21T09:39:14.470103+00:00"}