@article{oai:miyazaki-u.repo.nii.ac.jp:00000259,
 author = {内田, 和幸 and Uchida, Kazuyuki and 粟村, 雄一 and 中村, 智子 and Yamaguchi, Ryoji and 山口, 良二 and 立山, 晉 and Awamura, Yuichi and Nakamura, Tomoko},
 issue = {7},
 journal = {The journal of veterinary medical science},
 month = {Jul},
 note = {An anterior mediastinal cystic lesion in an 11-year-old mongrel dog was examined. The dog showed dysbasia and vomiting due to megaoesophagus, and anterior mediastinal round mass lesion, approximately 35 mm in diameter, was found by X ray. Based on clinical examinations, the dog was diagnosed as acquired myasthenia gravis and was successfully controlled by anticholinesterase treatment for approximately 4 months. The dog died of thermic stroke and was necropsied. Grossly, fatty tissues with cysts containing yellowish fluid and white nodules were found in the anterior mediastinal area. Histopathologically, multiple cysts, neoplastic tissues, and atrophic thymus were found within the examined tissues. The cysts were lined by thin wall consisting of ciliated long cuboidal and nonciliated round cells and were filled with eosinophilic colloidal fluid. Some extended cysts contained neoplastic foci within their lumen and walls. The neoplastic tissues consisted of mixed population of large epithelial cells with abundant clear cytoplasm and large oval nuclei, and lymphocytes. Immunohistochemically, proliferating epithelial cells were intensely positive for keratin and cytokeratin, and more than half number of infiltrating lymphocytes were intensely positive for CD3 suggesting T cells. All these findings indicate the neoplastic lesion is thymoma and multiple cysts are considered as thymic or brachial cleft cysts., 11歳雑種犬の前縦隔部に認められた嚢胞性病変を検索した.本例は虚脱と巨大食道症に起因する嘔吐を示し,X線により前縦隔部に直径約35mmの球形腫瘤病変が確認された.臨床試験により本例は後天性重症筋無力症と診断され,抗コリンエステラーゼ薬治療で約4ヶ月間良好に維持された.本例は熱性ショックにより死亡し剖検された.肉眼的に前縦隔部には,黄色調液体を貯留する嚢胞と白色結節を含む脂肪組織が認められた.組織学的に同組織には,多発性嚢胞,腫瘍組織,および萎縮した胸腺が含まれていた.嚢胞は長立方形の線毛上皮と円形非線毛上皮からなる薄い嚢胞壁から構成され,内部に好酸性コロイドを有していた.一部の拡張した嚢胞内及び嚢胞壁には腫瘍組織がみとめられ,この腫瘍組織は,淡明な細胞質と大型円形核を有する大型上皮細胞とリンパ球から構成されていた.免疫組織化学的に上皮細胞はケラチンおよびサイトケラチン強陽性で,浸潤していたリンパ球の半数以上がCD3陽性でありT細胞と考えられた.以上の検索結果より腫瘍性病変は胸腺腫,多発性嚢胞は胸腺嚢胞あるいは遺残鰓弓性嚢胞と考えられた.},
 pages = {637--640},
 title = {Thymoma and multiple thymic cysts in a dog with acquired myasthenia gravis},
 volume = {64},
 year = {2002},
 yomi = {ウチダ, カズユキ and アワムラ, ユウイチ and ナカムラ, トモコ and ヤマグチ, リョウジ and タテヤマ, ススム}
}