{"created":"2023-05-15T09:56:37.377834+00:00","id":254,"links":{},"metadata":{"_buckets":{"deposit":"71c4174a-1123-4fca-811a-30cff77eeb1e"},"_deposit":{"created_by":5,"id":"254","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"254"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00000254","sets":["74","74:26"]},"author_link":["949","940","937","956","955","957","958","950","952","951","959","948"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-05-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"546","bibliographicPageStart":"539","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"The journal of veterinary medical science","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The neurotoxicity of aniline and its age-dependent responses were investigated in male rats. Groups of 6 rats, 4-week-old, were treated once with aniline （500, 750 or 1,000 mg/kg） or olive oil by gavage. Additional groups of 6 rats, 7- or 10-week-old, were treated once with 800 mg/kg of aniline or olive oil. Paralytic gait or hindlimb paralysis was observed between post-treatment days 8 and 15 in two out of six rats receiving 1,000 mg/kg of aniline at 4 weeks of age. On post-treatment day 15, spongy change in the white matter of the spinal cord was observed in all rats receiving 750 or 1,000 mg/kg of aniline at 4 weeks of age. The lateral and ventral columns of the thoracic spinal cord were the most severely affected. Spongy change in the facial nerve and spinal trigeminal tracts of pons and medulla oblongata, and mild degeneration of the peripheral nerves was found in 3 out of 6 rats receiving 1,000 mg/kg of aniline. At the ultrastructural level, the spongy change was due to distention of the myclin sheath and splitting of the intraperiod line. Axons were well preserved in the affected nerve fibers. No abnormalities were seen in the neuronal cell bodies. Although transient cyanosis was observed in all rats receiving 800 mg/kg of aniline at 7- or 10-week-old, as well as in rats receiving 750 or 1,000 mg/kg of aniline at 4-week-old, no treatment-related neurobehavioral or morphologic abnormalities were found in the former. These findings demonstrate the neurotoxicity of orally administered aniline for rats, depending upon the age of the animal at the time of administration.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"アニリンの神経毒性誘発能と投与時週齢の違いによる神経毒性発現の感受性の違いを雄のSD系ラットを用いて検討した. アニリンの500, 750または1,000 mg/kgを4週齢のラットに, 800 mg/kgを7または10週齢のラットにそれぞれ単回経口投与し, 一般状態を15日間観察した. 7および10週齢ラットの投与量は, 過半数の動物が投与直後の急性影響で死亡しない最大の用量とした. 各々の週齢の動物にオリーブ油を投与する溶媒対照群を設けた. 動物数は各群6匹とした. 観察期間終了後に中枢および末梢神経組織の病理組織学的検査と脊髄の電子顕微鏡学的検査を行った. 4週齢時にアニリンの1,000 mg/kgを投与した6例中2例が投与後8～15日目に麻痺性歩行または後肢麻痺を呈した. 病理組織学的には脊髄白質の海綿状変化が750および1,000 mg/kg群の全例にみられた. 病変の程度は胸部脊髄の側索および腹索で強かった. 1,000 mg/kg群の6例中3例では橋および延髄に軽度の海綿状変化および軽度の末梢神経線維の変性が認められた. 脊髄の海綿状変化は髄鞘のintraperiod lineの解離によるものであった. 7または10週齢時にアニリンの800mg/kgを投与したラットには神経症状, 神経病変ともにみられなかった. 大量のアニリンをラットに単回経口投与することで神経毒性が誘発されることが確認された. また, この神経毒性の発現は投与時の週齢に依存し, 若齢ラットに投与した場合に限られることが示された.","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Society of Veterinary Science","subitem_publisher_language":"en"},{"subitem_publisher":"日本獣医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_18":{"attribute_name":"他の資源との関係","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://ci.nii.ac.jp/naid/110003920647/"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本獣医学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである","subitem_rights_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10796138","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09167250","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡崎, 欣正","creatorNameLang":"ja"},{"creatorName":"オカザキ, ヨシマサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山下, 弘太郎","creatorNameLang":"ja"},{"creatorName":"ヤマシタ, コウタロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"須藤, 雅人","creatorNameLang":"ja"},{"creatorName":"スドウ, マサト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"土谷, 稔","creatorNameLang":"ja"},{"creatorName":"ツチタニ, ミノル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"奈良間, 功","creatorNameLang":"ja"},{"creatorName":"ナラマ, イサオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Yamaguchi, Ryoji","creatorNameLang":"en"},{"creatorName":"山口, 良二","creatorNameLang":"ja"},{"creatorName":"ヤマグチ, リョウジ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"立山, 晉","creatorNameLang":"ja"},{"creatorName":"タテヤマ, ススム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okazaki, Yoshimasa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Kotaro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sudo, Masato","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuchitani, Minoru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Narama, Isao","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"jvms63_5_539.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JVMS63(5)539.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/254/files/jvms63_5_539.pdf"},"version_id":"6779f309-4d50-422a-8662-c8a1bd0ecbee"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"aniline, hindlimb paralysis, neurotoxicity, rat, spongy change with myelin vacuolation.","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Neurotoxicity Induced by a Single Oral Dose of Aniline in Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neurotoxicity Induced by a Single Oral Dose of Aniline in Rats","subitem_title_language":"en"},{"subitem_title":"アニリンをラットに単回経口投与することで誘発される神経毒性","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"5","path":["74","26"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-02-08"},"publish_date":"2008-02-08","publish_status":"0","recid":"254","relation_version_is_last":true,"title":["Neurotoxicity Induced by a Single Oral Dose of Aniline in Rats"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2023-09-02T12:45:53.556919+00:00"}