| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-03-23 |
| タイトル |
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タイトル |
Age-related decline in temporal sound processing: insights from envelope steepness map in the mouse auditory cortex |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
age-related decline |
| キーワード |
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言語 |
en |
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キーワード |
envelope steepness map |
| キーワード |
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言語 |
en |
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キーワード |
GCaMP6f |
| キーワード |
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言語 |
en |
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キーワード |
mouse auditory cortex |
| キーワード |
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言語 |
en |
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キーワード |
temporal sound processing |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Guo, Tianrui
髙橋, 邦行
WEKO
35246
e-Rad_Researcher
40452057
| ja |
髙橋, 邦行
宮崎大学
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| ja-Kana |
タカハシ, クニユキ
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| en |
Takahashi, Kuniyuki
University of Miyazaki
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Search repository
Ohshima, Shinsuke
Yamagishi, Tatsuya
Izumi, Shuji
Yagi, Chihiro
Kai, Ryota
Kimura, Akira
Tsukano, Hiroaki
Horii, Arata
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Introduction: Spectral information of speech sounds is spatially arranged from low to high frequencies in the auditory cortex, known as tonotopic maps. Recently, we identified an envelope steepness map encoding the rise-ramp steepness of sounds, which is located orthogonally to the tonotopic map. Temporal components, particularly the sound envelope defined by the rise-ramp steepness, play a crucial role in speech perception. We hypothesized that the ability to sense temporal components of sounds, such as envelope steepness, would be diminished in aged mice.
Methods: Responses to variations in rise-ramp time were investigated using transcranial macroscale calcium imaging of the auditory cortices of GCaMP6f-expressing mice. Normalized distance relative to the rise-ramp time of 0.01 ms was plotted for each rise-ramp time (0.1, 1, 10, and 100 ms) in the logarithmic scale graph: the steeper the slope of the fitted regression lines, the greater the distance between the peaks of the rise-ramp time of 0.01 ms and 100 ms. The slope of this regression line was compared between the different age groups: 1/3 months and 6/9/12 months after birth.
Results: The slope of the fitted regression line for 5 kHz in the bilateral anterior auditory field and 20 kHz in the bilateral primary auditory field was significantly less steep in mice at 6/9/12 months after birth than at 1/3 months after birth.
Conclusion: The shorter distance from the peak of 0.01 ms to 100 ms in animals 6/9/12 months after birth suggests difficulty in the separation of the rise-ramp time in aged animals. These findings may support the cortical mechanisms underlying age-related decline in speech perception. |
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言語 |
en |
| 書誌情報 |
en : Frontiers in Aging Neuroscience
巻 18,
p. 1730629,
発行日 2026-02-19
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| 出版者 |
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出版者 |
Frontiers Media SA |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
16634365 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
16634365 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3389/fnagi.2026.1730629 |
| 権利 |
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権利情報 |
© 2026 Guo, Takahashi, Ohshima, Yamagishi, Izumi, Yagi, Kai, Kimura, Tsukano and Horii. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
Fulltext (1.5 MB)
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