WEKO3
アイテム
Development of a non-invasive diagnostic method for pathogenic RNA viruses using sebum wiped from the cat's body surface
http://hdl.handle.net/10458/0002002409
http://hdl.handle.net/10458/0002002409f815bd90-5cc4-433b-a1c7-36d7c79243f9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2026-03-23 | |||||||||||||||||||||
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| タイトル | Development of a non-invasive diagnostic method for pathogenic RNA viruses using sebum wiped from the cat's body surface | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| キーワード | Feline immunodeficiency virus (FIV) | |||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||
| キーワード | Non-invasive detection of viral RNA | |||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||
| キーワード | Sebum | |||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||
| キーワード | Severe fever with thrombocytopenia syndrome | |||||||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||
| 著者 |
Fukushima, Yuri V
× Fukushima, Yuri V
× Saito, Namiko
× 目堅, 博久
WEKO
24382
× 齊藤, 暁
WEKO
33890
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| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | The development of non-invasive diagnostic methods for zoonotic viral infections is important for animal welfare and public health. Sebum-based diagnostic methods using commercial oil-blotting films have been used for SARS-CoV-2 detection in humans, but similar strategies for veterinary use remain unexplored. Severe fever with thrombocytopenia syndrome (SFTS), caused by the SFTS virus (SFTSV), presents a major health threat in Asia-especially in Japan, where multiple cases of cat-to-veterinarian transmission have been reported. To address this need for safer diagnostics, we sought to establish a sebum-based RNA virus detection method for cats. We designed primers that efficiently detected RNA from feline sebum while distinguishing it from human and feline DNA/RNA. Using this platform, we deemed the ear to be the optimal sebum collection site and confirmed that feline immunodeficiency virus RNA can be reliably identified from ear sebum with sensitivity comparable to conventional blood-based testing. Additionally, we detected SFTSV RNA from sebum samples of infected cat. Our findings introduce a minimally invasive, safe diagnostic platform for feline viral infections, reducing animal distress while safeguarding veterinarians and pet owners from zoonotic risks. This strategy is an important step toward realizing the One Health framework by advancing the well-being of animals and humans. | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 書誌情報 |
en : Scientific reports 巻 16, p. 4101, 発行日 2026-02-18 |
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| 出版者 | Springer Science and Business Media LLC | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 20452322 | |||||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/s41598-026-37655-z | |||||||||||||||||||||
| 権利 | ||||||||||||||||||||||
| 権利情報 | © The Author(s) 2026 | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||
