| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-03-10 |
| タイトル |
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タイトル |
Low-Extrusion-Force Injectable Chitosan Gel Microparticles for Effective Wound Dressing in Endoscopic Sinus Surgery |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
chitosan |
| キーワード |
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言語 |
en |
|
キーワード |
endoscopic sinus surgery |
| キーワード |
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言語 |
en |
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キーワード |
hydrogel |
| キーワード |
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|
言語 |
en |
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キーワード |
injectable |
| キーワード |
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|
言語 |
en |
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キーワード |
microparticles |
| キーワード |
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|
言語 |
en |
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キーワード |
wound dressing |
| キーワード |
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言語 |
en |
|
キーワード |
wound healing |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Nagase, Yuji
山下, 祐典
WEKO
35492
| ja |
山下, 祐典
宮崎大学
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| ja-Kana |
ヤマシタ, ユウスケ
|
| en |
Yamashita, Yusuke
University of Miyazaki
|
Search repository
Yoshinaga, Takuma
Ohzuno, Yoshihiro
Yoshida, Masahiro
Hosoya, Kei
Kawabata, Masaki
| en |
Kawabata, Masaki（Personal）
Kagoshima University Graduate School of Medical and Dental Sciences
|
Search repository
Yamashita, Masaru
| en |
Yamashita, Masaru（Personal）
Kagoshima University Graduate School of Medical and Dental Sciences
|
Search repository
Matsune, Shoji
Takei, Takayuki
| en |
Takei, Takayuki（Personal）
Kagoshima University Graduate School of Medical and Dental Sciences
|
Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Chitosan hydrogels are effective wound dressings that promote healing through the synergy of chitosan’s inherent biological properties and the moist environment they maintain. We previously developed hydrogel microparticles using a highly biocompatible chitosan derivative with superior therapeutic effects. This study aimed to enhance their clinical translation for Endoscopic Sinus Surgery (ESS) by optimizing preparation conditions to achieve an extrusion force of <20 N, facilitating ergonomic, single-handed administration by surgeons. While reducing the particle size alone was insufficient to lower the extrusion force significantly, the introduction of a mechanical “kneading” process to de-agglomerate microparticle aggregates resulted in a substantial reduction in the required force from 213 ± 80 N to approximately 47 N. By further optimizing the polymer concentration to 5.0% (w/v), we successfully reduced the maximum extrusion force to below 20 N (17 ± 1 N). These results demonstrate that the optimized injectable chitosan gel microparticles achieve the practical usability required for precise surgical maneuvers during ESS. |
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言語 |
en |
| 書誌情報 |
en : Eng
巻 7,
号 1,
p. 53,
発行日 2026-01-20
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| 出版者 |
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出版者 |
MDPI AG |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
26734117 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3390/eng7010053 |
| 権利 |
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権利情報 |
© 2026 by the authors. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
Fultext (1 MB)
.png)
