| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-02-19 |
| タイトル |
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タイトル |
Onnamides A and B Suppress Hepatitis B Virus Transcription by Inhibiting Viral Promoter Activity |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
キーワード |
hepatitis B virus |
| キーワード |
|
|
言語 |
en |
|
キーワード |
onnamides A and B |
| キーワード |
|
|
言語 |
en |
|
キーワード |
viral transcription inhibition |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
| 著者 |
林, 康広
WEKO
35370
e-Rad_Researcher
70582857
| ja |
林, 康広
宮崎大学
|
| ja-Kana |
ハヤシ, ヤスヒロ
|
| en |
Hayashi, Yasuhiro
University of Miyazaki
|
Search repository
Arizono, Sei
Higa, Nanami
Tyas, Trianda Ayuning
Akahori, Yuichi
Maeda, Kenji
Toyama, Masaaki
| en |
Toyama, Masaaki（Personal）
Japan Institute for Health Security (JIHS)
|
Search repository
Mori-Yasumoto, Kanami
Yasumoto-Hirose, Mina
Miyakawa, Kei
Tanaka, Junichi
Jomori, Takahiro
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
We recently reported that onnamide A, a marine-derived natural compound isolated from the sponge Theonella sp., inhibits the entry process of SARS-CoV-2 infection. However, its antiviral activity against other viruses remains largely unexplored. Here, we investigated the effects of onnamide A and its structurally related analog, onnamide B, on hepatitis B virus (HBV) infection. Using iNTCP cells, a hepatoblastoma-derived cell line permissive to HBV infection, we found that onnamides A and B exhibited cytotoxicity, with CC50 values of 0.53 ± 0.10 μM and 2.37 ± 0.25 μM, respectively. Following HBV infection, the levels of total HBV RNA were significantly reduced by onnamide A (IC50 = 0.06 ± 0.01 μM) and onnamide B (IC50 = 0.23 ± 0.06 μM). Notably, both compounds markedly decreased the levels of HBV pregenomic RNA. Furthermore, significant inhibition was particularly evident when onnamide treatment was initiated after HBV infection. Consistent with these observations, onnamides did not affect HBV binding, entry, or covalently closed circular DNA formation, but they significantly suppressed HBV RNA transcription. In particular, the transcriptional activities driven by the core and X promoters were markedly inhibited by onnamide treatment. Taken together, our findings demonstrate that onnamides possess potent anti-HBV activity and highlight their potential as candidate compounds targeting HBV RNA transcription. |
|
言語 |
en |
| 書誌情報 |
en : Marine drugs
巻 24,
号 1,
p. 21,
発行日 2026
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| 出版者 |
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|
出版者 |
MDPI AG |
|
言語 |
en |
| ISSN |
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|
収録物識別子タイプ |
EISSN |
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収録物識別子 |
16603397 |
| DOI |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.3390/md24010021 |
| 権利 |
|
|
権利情報 |
© 2026 by the authors. |
|
言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
Fulltext (1.4 MB)
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