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アイテム
Solution structure of Z-form DNA bound to a curaxin ligand CBL0137
http://hdl.handle.net/10458/0002002304
http://hdl.handle.net/10458/00020023044ba12682-3085-4fd7-833c-e33beffc2b02
| 名前 / ファイル | ライセンス | アクション |
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2026-02-18 | |||||||||||||||
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| タイトル | Solution structure of Z-form DNA bound to a curaxin ligand CBL0137 | |||||||||||||||
| 言語 | en | |||||||||||||||
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| 言語 | eng | |||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||
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| アクセス権 | open access | |||||||||||||||
| 著者 |
Liu, Feifan
× Liu, Feifan
× Wang, Shiyu
× 徐, 岩
WEKO
30154
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| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Z-DNA is known to be a left-handed alternative form of DNA and has important biological roles in cancer and other genetic diseases. In a recent study, we discovered CBL0137, a curaxin ligand, to enhance cancer immunotherapy by inducing Z-DNA formation and activating the Z-DNA-binding protein ZBP1. However, the structural information on binding complexes between Z-DNA and CBL0137 ligand has not reported to date. Here we present the first high-resolution structure of the complex between a Z-DNA and a curaxin ligand CBL0137. This compound is observed to interact with the Z-DNA through π-stacking and zig-zag localization. Furthermore, we directly observe the complex in living human cells using in-cell 19F NMR for the first time. This structural information provides a platform for the design of topology-specific Z-DNA-targeting compounds and is valuable for the development of new potent anticancer drugs. | |||||||||||||||
| 言語 | en | |||||||||||||||
| 書誌情報 |
en : Nucleic acids research 巻 54, 号 4, p. gkag104, 発行日 2026-02-27 |
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| 出版者 | Oxford University Press (OUP) | |||||||||||||||
| 言語 | en | |||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 13624962 | |||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | https://doi.org/10.1093/nar/gkag104 | |||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||
