| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-02-18 |
| タイトル |
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タイトル |
Continuity of long-term follow-up in patients with chronic hepatitis C after sustained virologic response following direct-acting antiviral therapy: a nationwide real-world multicenter cohort study in Japan |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
Follow-up continuity |
| キーワード |
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言語 |
en |
|
キーワード |
Hepatitis C virus |
| キーワード |
|
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言語 |
en |
|
キーワード |
Regional core centers |
| キーワード |
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言語 |
en |
|
キーワード |
SVR |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Ohara, Masatsugu
Kozuka, Ritsuzo
Uchida, Yoshihito
Iino, Chikara
Sasaki, Ryo
Tojima, Hiroki
Kawata, Kazuhito
| en |
Kawata, Kazuhito（Personal）
Hamamatsu University School of Medicine
|
Search repository
Kakizaki, Satoru
Tokumoto, Yoshio
Endo, Mizuki
Asai, Akira
| en |
Asai, Akira（Personal）
Osaka Medical and Pharmaceutical University
|
Search repository
Inoue, Jun
永田, 賢治
WEKO
7996
e-Rad_Researcher
00372798
| ja |
永田, 賢治
宮崎大学
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| ja-Kana |
ナガタ, ケンジ
|
| en |
Nagata, Kenji
University of Miyazaki
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Search repository
Takahashi, Hirokazu
Shimakami, Tetsuro
Ogawa, Koji
Enomoto, Masaru
Ikegami, Tadashi
Ide, Tatsuya
Sakamoto, Naoya
Korenaga, Masaaki
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background
Long-term follow-up is essential after a sustained virologic response (SVR) to direct-acting antivirals (DAAs) in patients with chronic hepatitis C. However, real-world continuity of care and determinants of disengagement are poorly characterized at the national level. Here, we quantified the follow-up continuity within Japan’s government-designated regional core centers and identified independent factors associated with transfer and self-discontinuation.
Methods
We conducted a retrospective multicenter cohort study of 3702 patients with chronic hepatitis C who achieved SVR at 16 regional core centers (2015–2018). Continuation was assessed using Kaplan–Meier analysis and competing-risk analysis, and Fine–Gray regression identified determinants of transfer and discontinuation.
Results
At 5 years, 56% of the patients were followed up, 24% were transferred, and 18% self-discontinued. Older age was significantly associated with transfer (subdistribution hazard ratio [sHR] 1.41, 95% CI 1.23–1.61), whereas hepatocellular carcinoma (HCC) and other malignancies favored continuous follow-up. Self-discontinuation was more frequent with hepatitis C virus (HCV) serotype 2 (sHR 1.36, 95% CI 1.18–1.57) and less common among patients with advanced disease or prior hospitalization.
Conclusions
Within Japan’s core-center network, long-term continuation after SVR is high but not universal. Follow-up was generally maintained for patients with severe comorbidities, while disengagement was more likely among those with lower perceived risk. Strengthening low-intensity, structured support for such patients may improve the continuity and equity of post-SVR care. These findings provide a foundation for optimizing post-SVR care pathways in national liver disease networks. |
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言語 |
en |
| 書誌情報 |
en : Journal of gastroenterology
発行日 2026-01-27
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| 出版者 |
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出版者 |
Springer Science and Business Media LLC |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
14355922 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1007/s00535-026-02345-0 |
| 権利 |
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権利情報 |
© The Author(s) 2026 |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
Fulltext (1 MB)
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