| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-02-13 |
| タイトル |
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タイトル |
Effectiveness of eprinomectin, albendazole and their combination therapy against strongyle nematode in dairy goats: A clinical field study using nemabiome-integrated approach in Thailand |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
|
キーワード |
Anthelmintic resistance |
| キーワード |
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言語 |
en |
|
キーワード |
Fecal egg count reduction |
| キーワード |
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|
言語 |
en |
|
キーワード |
Small ruminants |
| キーワード |
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言語 |
en |
|
キーワード |
Species-specific egg count reduction |
| キーワード |
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言語 |
en |
|
キーワード |
Strongyles |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Rompo, Thanakorn
Hayashi, Naoki
Hoketsu, Takaya
Teo, Ernest
Nonaka, Nariaki
Namboopha, Boondarika
Singhla, Tawatchai
Buddhasiri, Songphon
三澤, 尚明
WEKO
1864
e-Rad_Researcher
20229678
| ja |
三澤, 尚明
宮崎大学
|
| ja-Kana |
ミサワ, ナオアキ
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| en |
Misawa, Naoaki
University of Miyazaki
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Search repository
Nakao, Ryo
Tiwananthagorn, Saruda
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Strongyle nematodes are parasitic worms that significantly impact the health and productivity of livestock, including goats. Although infected goats are commonly treated with anthelmintics, reports of anthelmintic resistance have been increasing. This issue, along with limited treatment choices for goats and the lack of comprehensive anthelmintic resistance surveillance in Thailand, highlights the need to evaluate available drugs for effective parasite control. On a dairy goat farm in Chiang Mai, Thailand, a previous fecal egg count reduction test (FECRT) revealed resistance of strongyle nematodes to ivermectin, one of the most widely used anthelmintic drugs in the country. To further investigate treatment options, a clinical field study was conducted using the FECRT to evaluate the efficacy of eprinomectin at the label dose (0.2 mg/kg, n = 15 goats) and double dose (0.4 mg/kg, n = 9 goats), albendazole (20 mg/kg, n = 9 goats); and the combination of double dose eprinomectin and albendazole (n = 12 goats). Strongyle nematode species were identified through nemabiome analysis targeting the ITS-2 region of copro-DNA. Species-adjusted egg counts were calculated to determine species-specific egg count reduction (ECR). The FECRT results confirmed multi-anthelmintic resistance; however, species-specific ECR indicated varying susceptibility among species. Haemonchus contortus and Trichostrongylus colubriformis were the main contributors to the resistance, whereas Trichostrongylus axei and Oesophagostomum columbianum remained highly susceptible to eprinomectin and albendazole. These findings demonstrate the value of integrating FECRT with nemabiome to provide species-level insights into treatment responses, supporting the development of targeted deworming protocols and improving anthelmintic resistance surveillance in regions with limited treatment options. |
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言語 |
en |
| 書誌情報 |
en : Current Research in Parasitology and Vector Borne Diseases
巻 9,
p. 100345,
発行日 2026
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| 出版者 |
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出版者 |
Elsevier BV |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2667114X |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.crpvbd.2026.100345 |
| 権利 |
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権利情報 |
© 2026 The Authors. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
Fulltext (2.7 MB)
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