| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-02-04 |
| タイトル |
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タイトル |
Brief early antibiotic exposure (≤2 days) is not associated with disruption of gut microbiome in very low birth weight infants |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
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キーワード |
Bifidobacterium |
| キーワード |
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|
言語 |
en |
|
キーワード |
antibiotic exposure |
| キーワード |
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|
言語 |
en |
|
キーワード |
antibiotic stewardship |
| キーワード |
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|
言語 |
en |
|
キーワード |
gut microbiome |
| キーワード |
|
|
言語 |
en |
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キーワード |
microbial diversity |
| キーワード |
|
|
言語 |
en |
|
キーワード |
neonatal intensive care |
| キーワード |
|
|
言語 |
en |
|
キーワード |
preterm infants |
| キーワード |
|
|
言語 |
en |
|
キーワード |
very low birth weight infants |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
|
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アクセス権 |
open access |
| 著者 |
青木, 良則
WEKO
34963
e-Rad_Researcher
70726629
| ja |
青木, 良則
宮崎大学
|
| ja-Kana |
アオキ, ヨシノリ
|
| en |
Aoki, Yoshinori
University of Miyazaki
|
Search repository
楯, 真由美
WEKO
35262
| ja |
楯, 真由美
宮崎大学
|
| ja-Kana |
タテ, マユミ
|
| en |
Tate, Mayumi
University of Miyazaki
|
Search repository
Ochiai, Kayo
土持, 皓平
WEKO
35606
| ja |
土持, 皓平
宮崎大学
|
| ja-Kana |
ツチモチ, コウヘイ
|
| en |
Tsuchimochi, Kohei
University of Miyazaki
|
Search repository
Mizuguchi, Uiko
| en |
Mizuguchi, Uiko（Personal）
Tokyo Metropolitan Children's Medical Center
|
Search repository
Okazaki, Kaoru
| en |
Okazaki, Kaoru（Personal）
Tokyo Metropolitan Children's Medical Center
|
Search repository
盛武, 浩
WEKO
28692
e-Rad_Researcher
40336300
| ja |
盛武, 浩
宮崎大学
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| ja-Kana |
モリタケ, ヒロシ
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| en |
Moritake, Hiroshi
University of Miyazaki
|
Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Early empirical antibiotic therapy is common in preterm and very low birth weight (VLBW) infants but may disrupt the developing gut microbiome. However, the effects of brief antibiotic courses remain unclear, particularly in the most immature infants. In this prospective multicenter cohort study, we examined gut microbiome trajectories in VLBW infants (many of whom were extremely preterm) receiving no antibiotics, a short course (≤2 days), or prolonged exposure (≥3 days). Serial stool samples were analyzed using 16S rRNA gene sequencing. Microbiome composition and diversity in the short-course group were similar to those in unexposed infants at all timepoints, indicating that brief antibiotic exposure did not disrupt microbial development. In contrast, prolonged exposure was associated with transient dysbiosis characterized by reduced Bifidobacterium abundance and lower alpha diversity, with partial recovery by discharge. These findings suggest that limiting empirical antibiotic therapy to ≤2 days (48 h) when infection is unconfirmed may not disrupt microbiome development even in highly immature preterm VLBW infants, supporting evidence-based antibiotic stewardship in neonatal intensive care. |
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言語 |
en |
| 書誌情報 |
en : Frontiers in microbiology
巻 16,
p. 1742512,
発行日 2026-01-14
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| 出版者 |
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出版者 |
Frontiers Media SA |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1664302X |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3389/fmicb.2025.1742512 |
| 権利 |
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|
権利情報 |
© 2026 Aoki, Tate, Ochiai, Tsuchimochi, Mizuguchi, Okazaki and Moritake. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
Fulltext (1.3 MB)
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