| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-01-29 |
| タイトル |
|
|
タイトル |
Diversity in chemosensory receptor genes in dogs and wolves: degeneration of the olfactory receptor gene repertoire in the brachycephalic Pug |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
キーワード |
copy number variation |
| キーワード |
|
|
言語 |
en |
|
キーワード |
domestication |
| キーワード |
|
|
言語 |
en |
|
キーワード |
gene family evolution |
| キーワード |
|
|
言語 |
en |
|
キーワード |
single nucleotide variant |
| キーワード |
|
|
言語 |
en |
|
キーワード |
taste receptor |
| キーワード |
|
|
言語 |
en |
|
キーワード |
vomeronasal receptor |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
| 著者 |
Inoue, Hyuga
Gibbs, Matthew
McGrane, Scott J
新村, 芳人
WEKO
35347
e-Rad_Researcher
90396979
| ja |
新村, 芳人
宮崎大学
|
| ja-Kana |
ニイムラ, ヨシヒト
|
| en |
Niimura, Yoshihito
University of Miyazaki
|
Search repository
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Dogs, domesticated from gray wolves over 15,000 yr ago, exhibit extensive variation among breeds, including differences in olfactory ability. To investigate the genetic basis of these differences, we analyzed single-nucleotide variants (SNVs) in 3 chemosensory receptor gene families-olfactory receptors (ORs), vomeronasal receptors type 1 (V1Rs), and bitter taste receptors (T2Rs)-using whole-genome data from the Dog Biomedical Variant Database Consortium, which includes 635 domestic dogs representing 121 breeds and 8 wolves. We identified 179 segregating pseudogenes in OR genes (minor allele frequency > 1%), including cases where intact genes are pseudogenized in some individuals and vice versa. The number of functional OR genes varied substantially among individuals (779 to 807), while V1R and T2R gene counts were nearly invariant (8 and 16, respectively). Compared to wolves, dogs exhibited significantly higher ratios of nonsynonymous to synonymous SNVs (N/S) in OR and T2R genes, suggesting relaxed functional constraints potentially associated with domestication. Among breeds, Pugs had significantly fewer functional OR genes and a higher N/S ratio than other breeds, even after accounting for copy number variation. Notably, an OR gene orthologous to the human androstenone receptor, OR7D4, was completely pseudogenized in all Pugs but remained largely functional in other breeds. These findings support the hypothesis that reduced olfactory ability in brachycephalic breeds, such as Pugs, is associated with genetic degeneration of OR genes. Overall, our study provides new insights into the genetic diversity of chemosensory receptor repertoires in dogs and underscores the impact of domestication and breed-specific morphological traits on olfactory function. |
|
言語 |
en |
| 書誌情報 |
en : Chemical senses
巻 50,
p. bjaf062,
発行日 2025-12-15
|
| 出版者 |
|
|
出版者 |
Oxford University Press |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
14643553 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1093/chemse/bjaf062 |
| 権利 |
|
|
権利情報 |
© The Author(s) 2025. |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
Fulltext (1 MB)
.png)
