| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-01-19 |
| タイトル |
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タイトル |
Lactiplantibacillus plantarum Strain 06CC2 Attenuates Fat Accumulation and Modulates the Gut Microbiota in a Mouse Model of Early-Stage Diet-Induced Obesity |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
16S rRNA sequencing |
| キーワード |
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言語 |
en |
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キーワード |
Lactiplantibacillus plantarum |
| キーワード |
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言語 |
en |
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キーワード |
adipose tissue inflammation |
| キーワード |
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言語 |
en |
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キーワード |
diet-induced obesity |
| キーワード |
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言語 |
en |
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キーワード |
gut microbiota |
| キーワード |
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言語 |
en |
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キーワード |
hepatic steatosis |
| キーワード |
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言語 |
en |
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キーワード |
mice |
| キーワード |
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言語 |
en |
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キーワード |
probiotics |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Matsusaki, Tatsuya
Takakura, Chisato
Ichitani, Kaho
Tsend-Ayush, Chuluunbat
| en |
Tsend-Ayush, Chuluunbat（Personal）
Mongolian University of Science and Technology
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Search repository
片岡, 寛章
WEKO
9886
e-Rad_Researcher
10214321
| ja |
片岡, 寛章
宮崎大学
|
| ja-Kana |
カタオカ, ヒロアキ
|
| en |
Kataoka, Hiroaki
University of Miyazaki
|
Search repository
福島, 剛
WEKO
9884
e-Rad_Researcher
10452913
| ja |
福島, 剛
宮崎大学
|
| ja-Kana |
フクシマ, ツヨシ
|
| en |
Fukushima, Tsuyoshi
University of Miyazaki
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Search repository
Kurogi, Junko
Nishiyama, Kazuo
小川, 健二郎
WEKO
35059
e-Rad_Researcher
70840700
| ja |
小川, 健二郎
宮崎大学
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| ja-Kana |
オガワ, ケンジロウ
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| en |
Ogawa, Kenjiro
University of Miyazaki
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Search repository
Shinyama, Takuo
Nakano, Tomoki
山﨑, 正夫
WEKO
18975
e-Rad_Researcher
80381060
| ja |
山﨑, 正夫
宮崎大学
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| en |
Yamasaki, Masao
University of Miyazaki
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| ja-Kana |
ヤマサキ, マサオ
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Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background/Objectives: The increase in the global prevalence of obesity has created a need for safe and effective preventive strategies. Probiotics have gained attention for their potential to modulate the gut microbiota and improve metabolic health. In this study, we examined the anti-obesity effects of Lactiplantibacillus plantarum strain 06CC2 (LP06CC2) in a mouse model of mild diet-induced obesity that mimics early-stage metabolic imbalance without significant body weight gain. Methods: Mice were fed a high-fat diet for 8 weeks, with or without LP06CC2 supplementation. Biochemical assays were used to determine the metabolic effects of LP06CC2, and 16S rRNA sequencing was performed to analyze the gut microbiota. Results: LP06CC2 attenuated epididymal fat accumulation and adipocyte hypertrophy, improved the gene expression profiles related to lipid metabolism and inflammation in adipose tissue, and reduced early hepatic steatosis. 16S rRNA sequencing revealed that LP06CC2 modulated the diversity and composition of the gut microbiota, notably suppressing HFD-induced increases in Mucispirillum schaedleri and other taxa associated with inflammation. LP06CC2-treated mice exhibited higher alpha diversity and partial restoration of their microbial profiles toward those of the normal diet-fed animals. LP06CC2 also downregulated pro-inflammatory cytokines and genes related to lipid uptake while modulating markers of thermogenesis and lipolysis. Conclusions: These findings indicate that LP06CC2 can prevent fat accumulation and gut dysbiosis in the pre-obese state, supporting its potential as a functional food ingredient for early intervention in obesity. Further human trials and studies using advanced obesity models are warranted to confirm its efficacy and elucidate its underlying mechanisms of action. |
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言語 |
en |
| 書誌情報 |
en : Nutrients
巻 17,
号 24,
p. 3855,
発行日 2025-12-10
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| 出版者 |
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出版者 |
MDPI AG |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
20726643 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3390/nu17243855 |
| 権利 |
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権利情報 |
© 2025 by the authors. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
Fulltext (7.3 MB)
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