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  1. 医学部
  1. 医学部
  2. 学術雑誌掲載論文  (医学部)

Surgical Outcomes and Diagnostic Concordance in Patients With Pancreatic Neuroendocrine Tumors Undergoing Pancreatectomy: A Retrospective Cohort Study

http://hdl.handle.net/10458/0002002202
http://hdl.handle.net/10458/0002002202
7623c0cc-0834-4f3f-aecf-fa58ed5ca2b7
名前 / ファイル ライセンス アクション
cdp-6-52.pdf Fulltext (432 KB)
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アイテムタイプ 学術雑誌論文 / Journal Article(1)
公開日 2026-01-19
タイトル
タイトル Surgical Outcomes and Diagnostic Concordance in Patients With Pancreatic Neuroendocrine Tumors Undergoing Pancreatectomy: A Retrospective Cohort Study
言語 en
言語
言語 eng
キーワード
言語 en
キーワード Pancreatic neuroendocrine tumor
キーワード
言語 en
キーワード diagnostic concordance
キーワード
言語 en
キーワード pancreatectomy
キーワード
言語 en
キーワード prognostic factors
キーワード
言語 en
キーワード surgical outcomes
資源タイプ
資源タイプ journal article
アクセス権
アクセス権 open access
著者 七島, 篤志

× 七島, 篤志

WEKO 33886
e-Rad_Researcher 60380838

ja 七島, 篤志
宮崎大学

ja-Kana ナナシマ, アツシ

en Nanashima, Atsushi
University of Miyazaki

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Hiyoshi, Masahide

× Hiyoshi, Masahide

en Hiyoshi, Masahide(Personal)
University of Miyazaki

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今村, 直哉

× 今村, 直哉

WEKO 19941
e-Rad_Researcher 30423718

ja 今村, 直哉
宮崎大学

ja-Kana イマムラ, ナオヤ

en Imamura, Naoya
University of Miyazaki

Search repository
土持, 有貴

× 土持, 有貴

WEKO 34900
e-Rad_Researcher 60770229

ja 土持, 有貴
宮崎大学

ja-Kana ツチモチ, ユウキ

en Tsuchimochi, Yuki
University of Miyazaki

Search repository
和田, 敬

× 和田, 敬

WEKO 35523
e-Rad_Researcher 30783980

en Wada, Takashi(Personal)
University of Miyazaki

ja 和田, 敬
宮崎大学

ja-Kana ワダ, タカシ

Search repository
濵田, 剛臣

× 濵田, 剛臣

WEKO 34334

en Hamada, Takeomi
University of Miyazaki

ja-Kana ハマダ, タケオミ

ja 濵田, 剛臣
宮崎大学

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鈴木, 康人

× 鈴木, 康人

WEKO 33632
e-Rad_Researcher 81014777

ja 鈴木, 康人
宮崎大学

ja-Kana スズキ, ヤスト

en Suzuki, Yasuto
University of Miyazaki

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Araki, Yuusuke

× Araki, Yuusuke

en Araki, Yuusuke(Personal)
University of Miyazaki

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抄録
内容記述タイプ Abstract
内容記述 Background/Aim
Pancreatic neuroendocrine tumors (PanNETs) are heterogeneous neoplasms for which surgical resection remains the only potentially curative therapy. However, preoperative diagnostic accuracy - particularly tumor grading - often varies, complicating treatment decisions. This study evaluated diagnostic concordance between preoperative assessments and postoperative pathology, as well as surgical outcomes and prognostic factors in patients undergoing pancreatectomy for PanNETs.
Patients and Methods
We retrospectively reviewed the clinical records of 32 patients who underwent surgical resection for PanNETs. Patient demographics, tumor characteristics, surgical procedures, and postoperative outcomes were analyzed. Preoperative imaging and cytology-based diagnoses were compared with final pathological findings to evaluate diagnostic concordance. Prognostic factors were assessed using Kaplan-Meier survival analysis.
Results
Histological grading of resected specimens showed G1 in 53%, G2 in 41%, and G3/NEC in 6%, with a 38% discordance rate from preoperative biopsy. Lymphatic, venous, and perineural invasions were identified in 16%, 44%, and 13% of cases. Lymph node metastasis occurred in 22%. Among 30 patients with follow-up >12 months, eight developed recurrence, most commonly in the liver. The 3-year and 5-year disease-free survival (DFS) rates were 78% and 69%, while overall survival (OS) rates were 96% and 91%. Tumor number >2 and histologic grade G3 were significantly associated with reduced DFS (p<0.05). Lymphatic invasion and metachronous liver metastasis were significantly associated with reduced OS (p<0.01 and p<0.05, respectively). Histological grading mismatch was not associated with survival outcomes.
Conclusion
Pancreatectomy for PanNETs is a safe and effective treatment with favorable long-term outcomes. Histological factors such as tumor grade, lymphatic invasion, and tumor number significantly predict recurrence and survival.
言語 en
書誌情報 en : Cancer diagnosis & prognosis

巻 6, 号 1, p. 52-61, 発行日 2026-01-03
出版者
出版者 International Institute of Anticancer Research
言語 en
ISSN
収録物識別子タイプ EISSN
収録物識別子 27327787
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.21873/cdp.10506
権利
権利情報 ©2026 The Author(s).
言語 en
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出版タイプ VoR
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