| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-01-16 |
| タイトル |
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タイトル |
Clinical features of Mycobacterium abscessus complex and Mycobacterium kansasii pulmonary disease in Kyushu, Japan |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
Mycobacterium abscessus |
| キーワード |
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言語 |
en |
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キーワード |
Mycobacterium kansasii |
| キーワード |
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言語 |
en |
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キーワード |
Prognosis |
| キーワード |
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言語 |
en |
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キーワード |
Treatment |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Takeda, Kazuaki
Takazono, Takahiro
Ide, Shotaro
Yoshida, Masataka
Iwanaga, Naoki
Hosogaya, Naoki
Tsukamoto, Yusei
Irifune, Satoshi
Suyama, Takayuki
Umemura, Asuka
Mihara, Tomo
| en |
Mihara, Tomo（Personal）
Japan Community Health care Organization Isahaya General Hospital
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Search repository
Kondo, Akira
| en |
Kondo, Akira（Personal）
National Hospital Organization Nagasaki Medical Center
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Search repository
Kobayashi, Tsutomu
Sasaki, Eisuke
| en |
Sasaki, Eisuke（Personal）
National Hospital Organization Ureshino Medical Center
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Search repository
Sawai, Toyomitsu
| en |
Sawai, Toyomitsu（Personal）
National Hospital Organization Ureshino Medical Center
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Search repository
Higashiyama, Yasuhito
Hashiguchi, Kohji
| en |
Hashiguchi, Kohji（Personal）
Japanese Red Cross Nagasaki Genbaku Hospital
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Search repository
Hanaka, Minako
Ii, Toshihiko
Fukushima, Kiyoyasu
| en |
Fukushima, Kiyoyasu（Personal）
Japanese Red Cross Nagasaki Genbaku Isahaya Hospital
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Search repository
Komiya, Kosaku
宮崎, 泰可
WEKO
34876
| ja |
宮崎, 泰可
宮崎大学
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| ja-Kana |
ミヤザキ, タイガ
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| en |
Miyazaki, Taiga
University of Miyazaki
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Search repository
Yatera, Kazuhiro
| en |
Yatera, Kazuhiro（Personal）
University of Occupational and Environmental Health
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Search repository
Izumikawa, Koichi
Furumoto, Akitsugu
Yanagihara, Katsunori
Mukae, Hiroshi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background
Nontuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic respiratory infection with a growing incidence and mortality globally. Although the clinical features, treatment, and prognosis of Mycobacterium avium-intracellulare (MAI) pulmonary disease have been extensively reported, evidence regarding non-MAI NTM-PD remains limited.
Methods
This retrospective cohort study included patients newly diagnosed with NTM-PD between 2010 and 2017 at 18 hospitals in Kyushu, Japan. Data on baseline characteristics, causative organisms, radiological findings, treatment regimens, and clinical outcomes were collected and analysed.
Results
In total, 1317 patients were enrolled. M. intracellulare (50.4 %), M. avium (40.5 %), M. abscessus complex (MABC) (2.4 %), and M. kansasii (2.4 %) were identified as the major causative organisms. Compared with patients with MAI, those with MABC exhibited a lower body mass index and a higher AFB sputum smear positivity rate. Patients with M. kansasii infection were predominantly male, frequently had underlying chronic obstructive pulmonary disease, and presented with cavitary lesions. Treatment initiation rates for MABC and M. kansasii were 71.9 % and 87.5 %, respectively. The response rate to the treatment in sputum mycobacterial evaluation was comparable between the two groups. However, the re-treatment rate was higher in the MABC group (30.4 % vs. 14.3 %). The 10-year mortality rates were 25.0 % and 15.6 % for MABC and M. kansasii, respectively.
Conclusions
Initial treatment responses for MABC and M. kansasii were favourable. However, long-term outcomes for MABC remained poor, potentially owing to the limited availability of effective continuation-phase therapies. Further large-scale prospective studies are warranted to understand the clinical management and prognosis of non-MAI NTM-PD. |
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言語 |
en |
| 書誌情報 |
en : Respiratory Investigation
巻 64,
号 1,
p. 101358
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| 出版者 |
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出版者 |
Elsevier BV |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
22125353 |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
22125345 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.resinv.2025.101358 |
| 権利 |
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|
権利情報 |
© 2025 The Authors. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
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