WEKO3
アイテム
Ante-mortem glutathione peroxidase 4 inhibition by RSL3 affects post-mortem meat quality in broiler chickens
http://hdl.handle.net/10458/0002002061
http://hdl.handle.net/10458/00020020614200b86d-2a71-45b1-9151-6268c7f93697
| 名前 / ファイル | ライセンス | アクション |
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Manuscript (596 KB)
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This is an Accepted Manuscript of an article published by Taylor & Francis in British Poultry Science on 2024-10-25, available at: https://doi.org/10.1080/00071668.2024.2412167
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2025-12-22 | |||||||||||||||||||||||
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| タイトル | Ante-mortem glutathione peroxidase 4 inhibition by RSL3 affects post-mortem meat quality in broiler chickens | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| キーワード | chicken | |||||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||||
| キーワード | ferroptosis | |||||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||||
| キーワード | Glutathione peroxidase 4 | |||||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||||
| キーワード | meat quality | |||||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||||
| キーワード | redox | |||||||||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
| 著者 |
仲西, 友紀
× 仲西, 友紀
WEKO
35323
× Uchiyama, T.
× Uchida, M.
× Erickson, L.
× 河原, 聡
WEKO
1788
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| 内容記述タイプ | Abstract | |||||||||||||||||||||||
| 内容記述 | 1. This study investigated the role of glutathione peroxidase 4 (GPX4), a key regulator of ferroptosis, a form of programmed cell death, in muscle biochemistry and meat quality, utilising broiler chickens whose ante-mortem GPX4 activity was inhibited pharmacologically. 2. Male broilers were divided into two groups, each receiving ante-mortem administration of the GPX4 inhibitor, Ras-selective lethal 3 (RSL3), or a vehicle only. After slaughter, breast muscles were collected and stored for 48 h. The expressions of ferroptosis-related genes, glutathione levels, pH, colour and water-holding capacity were evaluated at multiple time points during the storage period. 3. The RSL3 treatment decreased the expression of GPX4 and ferritin heavy chain 1, which are negative regulators of ferroptosis, while it increased the expression of a ferroptosis accelerator, acyl-CoA synthetase long chain family member 4. The ratio of reduced to oxidised glutathione was significantly decreased in the RSL3 group. The RSL3 treatment decelerated post-mortem pH decline and colour changes, such as a decrease in L* and an increase in a* were observed in the RSL3 group. In addition, the RSL3 group showed increased levels of water-holding capacity. 4. These findings suggested that ante-mortem GPX4 activity plays a role in determining meat quality, implying the possible involvement of ferroptosis in the mechanism by which skeletal muscle is converted after slaughter into meat that is eaten. |
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| 言語 | en | |||||||||||||||||||||||
| 書誌情報 |
en : British Poultry Science 巻 66, 号 2, p. 218-226, 発行日 2024-10-25 |
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| 出版者 | ||||||||||||||||||||||||
| 出版者 | Informa UK Limited | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||
| 収録物識別子 | 14661799 | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 00071668 | |||||||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1080/00071668.2024.2412167 | |||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||
| 権利情報 | © 2024 British Poultry Science Ltd | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 出版タイプ | AM | |||||||||||||||||||||||
