| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-12-08 |
| タイトル |
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タイトル |
Safety and efficacy of arsenic trioxide in intensification therapy for newly diagnosed childhood acute promyelocytic leukemia: results from the JPLSG AML-P13 study |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
Acute promyelocytic leukemia |
| キーワード |
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言語 |
en |
|
キーワード |
Arsenic trioxide |
| キーワード |
|
|
言語 |
en |
|
キーワード |
Childhood leukemia |
| キーワード |
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言語 |
en |
|
キーワード |
Clinical trial |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
| 著者 |
Takahashi, Hiroyuki
Tanaka, Shiro
Yuza, Yuki
| en |
Yuza, Yuki（Personal）
Tokyo Metropolitan Children's Medical Center
|
Search repository
Iijima-Yamashita, Yuka
Hasegawa, Daisuke
盛武, 浩
WEKO
28692
e-Rad_Researcher
40336300
| ja |
盛武, 浩
宮崎大学
|
| ja-Kana |
モリタケ, ヒロシ
|
| en |
Moritake, Hiroshi
University of Miyazaki
|
Search repository
Terui, Kiminori
Iwamoto, Shotaro
Shimada, Akira
Matsubayashi, Jun
Deguchi, Takao
| en |
Deguchi, Takao（Personal）
National Center for Child Health and Development
|
Search repository
Hashii, Yoshiko
Kiyokawa, Nobutaka
| en |
Kiyokawa, Nobutaka（Personal）
National Center for Child Health and Development
|
Search repository
Miyachi, Hayato
Saito, Akiko M
Taga, Takashi
Adachi, Souichi
Tomizawa, Daisuke
| en |
Tomizawa, Daisuke（Personal）
National Center for Child Health and Development
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Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Arsenic trioxide (ATO) in combination with all-trans retinoic acid (ATRA) has been shown to be effective in both adult and pediatric patients with acute promyelocytic leukemia (APL). Addition of ATO to conventional chemotherapy could lead to a reduction in the doses of cytotoxic agents, but the long-term safety of ATO is not fully understood, especially in children. The Japan Children's Cancer Group conducted a risk-stratified prospective study to investigate safety and efficacy of ATO in children with newly diagnosed APL by replacing all three intensification phases with ATO. The 3-year event-free survival and overall survival rates in 27 children were 96.3% (95% CI 76.5%-99.5%) and 100% (95% CI 87.2%-100%), respectively. Prolonged QTc interval or other cardiac conduction disorders of any grade were observed in 20 out of the 63 intensification cycles. The durations of leukocytopenia, neutropenia, and G-CSF treatment were significantly shorter in this study than in a previous Japanese study that used conventional cytotoxic chemotherapy. Furthermore, no cardiac, metabolic, renal, cutaneous, or neurological symptoms were reported for up to 5 years after completion of the protocol therapy. The JPLSG AML-P13 study demonstrated excellent outcomes and safety of ATO in children with APL. |
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言語 |
en |
| 書誌情報 |
en : International journal of hematology
発行日 2025-09-04
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| 出版者 |
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出版者 |
Springer Nature |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
18653774 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1007/s12185-025-04060-7 |
| 著者版フラグ |
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出版タイプ |
NA |
