| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-12-03 |
| タイトル |
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タイトル |
Baseline Relationships between Visual Function and Inflammatory Markers in the Registry of Moderated-Stage Retinitis Pigmentosa |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
Aqueous flare |
| キーワード |
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言語 |
en |
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キーワード |
Prospective study |
| キーワード |
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言語 |
en |
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キーワード |
Registry data |
| キーワード |
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言語 |
en |
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キーワード |
Retinitis Pigmentosa |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Hisai, Takahiro
Shimokawa, Sakurako
Fukushima, Masatoshi
Fujiwara, Kohta
Koyanagi, Yoshito
Hirata, Akie
Takada, Atsushi
Miyahara, Fuyuka
Nakashima, Naoki
Kobayakawa, Yuko
Mawatari, Go
石津, 正崇
WEKO
34986
e-Rad_Researcher
90968629
| ja |
石津, 正崇
宮崎大学
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| ja-Kana |
イシズ, マサタカ
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| en |
Ishizu, Masataka
University of Miyazaki
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Search repository
Toyama, Naoki
Kaida, Tomoko
Miyata, Kazunori
| en |
Miyata, Kazunori（Personal）
Miyata Eye Hospital, Miyazaki, Japan.
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Search repository
池田, 康博
WEKO
34979
e-Rad_Researcher
20380389
| ja |
池田, 康博
宮崎大学
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| ja-Kana |
イケダ, ヤスヒロ
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| en |
Ikeda, Yasuhiro
University of Miyazaki
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Search repository
Sonoda, Koh-Hei
Murakami, Yusuke
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Purpose
To analyze the association between visual function and inflammatory markers in the baseline data of a prospective natural history registry of patients with typical retinitis pigmentosa (RP) (Retinitis Pigmentosa Progression and Inflammatory Marker Registry Study [RP-PRIMARY Study]).
Design
A cross-sectional observational study using baseline data from the RP-PRIMARY study.
Participants
A total of 67 patients with moderate-stage typical RP who were treated between October 2021 and October 2022 in 1 of 3 participating hospitals consented to participate and met the inclusion criteria.
Methods
Visual functions were ETDRS best-corrected visual acuity (BCVA), Humphrey Field Analyzer 10-2 program (mean deviation value, and the mean sensitivity within the central 1° area [central 4 points, RS Cent 1’] and the 4° area [central 12 points, RS Cent 4’]), ellipsoid zone (EZ) length, central foveal thickness (CFT), hyper-autofluorescence (AF) ring area, and inflammatory markers were aqueous flare and blood test measurements.
Main Outcome Measures
Association between visual function and inflammatory markers.
Results
The median age of participants was 51 (interquartile range: 43–60) years. Spearman rank correlation coefficient demonstrated that aqueous flare values were negatively correlated with ETDRS BCVA (ρ = –0.35; P = 0.004), RS Cent 1’ (ρ = –0.32; P = 0.008), EZ length (ρ = –0.28; P = 0.023), and hyper-AF ring area (ρ = –0.31; P = 0.016). There was no significant correlation between systemic inflammatory markers and visual function. Eyes with intraocular lens (IOL) had significantly lower values of ETDRS BCVA (P = 0.004), RS Cent 1’ (P = 0.005), RS Cent 4’ (P = 0.010), CFT (P = 0.001), and EZ length (P = 0.011), in addition to higher values of aqueous flare (P < 0.001). Multiple linear regression analysis revealed that eyes with IOL (β = 0.262; P < 0.001) were significantly associated with aqueous flare.
Conclusions
In the baseline data of the RP-PRIMARY study, aqueous flare, an ocular inflammatory marker, was negatively associated with visual function, and IOL implantation was most strongly associated with an increase in aqueous flare in patients with moderate-stage RP. The association between inflammatory markers and disease progression will be evaluated in the ongoing RP-PRIMARY study. |
|
言語 |
en |
| 書誌情報 |
en : Ophthalmology science
巻 6,
号 1,
p. 100930,
発行日 2026-01
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| 出版者 |
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出版者 |
Elsevier BV |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
26669145 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.xops.2025.100930 |
| 著者版フラグ |
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出版タイプ |
VoR |
fulltext (2.3 MB)
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