| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-10-28 |
| タイトル |
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タイトル |
Efficacy of favipiravir treatment for patients with severe fever with thrombocytopenia syndrome assessed with a historical control |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
|
|
言語 |
en |
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キーワード |
Bandavirus dabieense |
| キーワード |
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言語 |
en |
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キーワード |
SFTS |
| キーワード |
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言語 |
en |
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キーワード |
SFTS virus |
| キーワード |
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言語 |
en |
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キーワード |
favipiravir |
| キーワード |
|
|
言語 |
en |
|
キーワード |
severe fever with thrombocytopenia syndrome |
| キーワード |
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言語 |
en |
|
キーワード |
tick-borne virus infection |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Saijo, Masayuki
| en |
Saijo, Masayuki（Personal）
National Institute of Infectious Diseases
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Search repository
Izumikawa, Koichi
Suemori, Koichiro
Takahashi, Toru
| en |
Takahashi, Toru（Personal）
Yamaguchi Prefectural Grand Medical Center
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Search repository
梅北, 邦彦
WEKO
21827
e-Rad_Researcher
20506084
| ja |
梅北, 邦彦
宮崎大学
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| ja-Kana |
ウメキタ, クニヒコ
|
| en |
Umekita, Kunihiko
University of Miyazaki
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Search repository
Ohge, Hiroki
Hatakenaka, Mariko
Ikeda, Kenichi
Himeji, Daisuke
| en |
Himeji, Daisuke（Personal）
Miyazaki Prefectural Miyazaki Hospital
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Search repository
Yamanaka, Atushi
| en |
Yamanaka, Atushi（Personal）
Miyazaki Prefectural Miyazaki Hospital
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Search repository
Kadowaki, Norimitsu
Kawamura, Masafumi
| en |
Kawamura, Masafumi（Personal）
Kochi Prefectural Hata Kenmin Hospital
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Search repository
Kakihana, Yasuyuki
Ito, Takuo
| en |
Ito, Takuo（Personal）
NHO Kure Medical Center and Chugoku Cancer Center
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Search repository
Nosaka, Kisato
Sakurai, Tsutomu
Yoshikawa, Tomoki
| en |
Yoshikawa, Tomoki（Personal）
National Institute of Infectious Diseases
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Search repository
Kurosu, Takeshi
| en |
Kurosu, Takeshi（Personal）
National Institute of Infectious Diseases
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Search repository
Shimojima, Masayuki
| en |
Shimojima, Masayuki（Personal）
National Institute of Infectious Diseases
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Search repository
Yasukawa, Masaki
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Severe fever with thrombocytopenia syndrome (SFTS) is a disease caused by SFTS virus (SFTSV), an RNA virus, and endemic to Asia. The case fatality rate in Japan is estimated to be approximately 27%. Currently, no efficacious drugs are available. Favipiravir (FPV) has the potential to treat SFTS. However, no quantitative studies comparing FPV with conventional treatments have been conducted in the country. We conducted an open-label, interventional study in which patients with SFTS were administered FPV 1800 mg twice on the first day, followed by 800 mg twice daily for nine days. Additionally, we performed a retrospective observational study on patients with SFTS who received the best supportive care (BSC) without FPV treatment by collecting medical data from individuals at the same institutions. Patients aged 20-85 years were recruited, and blood samples were collected on Days 0 (pre-dose), 1, 3, 6, 9, 14, and 27 in the interventional study. Outcomes and laboratory parameters were compared by 1:1 matching using propensity score (PS). Thirty and 78 patients were enrolled in the FPV and the BSC groups, respectively. Twenty-three pairs were identified by PS matching. The risk ratio of fatality for the FPV group compared to the BSC group reduced to 0.500 after matching. Ferritin levels associated with hemophagocytosis severity were significantly different between the FPV and BSC groups on Days 3 to 9 after matching. No concerning serious adverse events were observed in the FPV group.This interventional study has been registered with the Japan Registry of Clinical Trials as jRCT2080223816. |
|
言語 |
en |
| 書誌情報 |
en : Antimicrobial agents and chemotherapy
p. e0106225,
発行日 2025-10-17
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| 出版者 |
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出版者 |
American Society for Microbiology |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
10986596 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1128/aac.01062-25 |
| 著者版フラグ |
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出版タイプ |
VoR |
fulltext (1.4 MB)
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