| 著者 |
釘宮, 啓一
WEKO
35128
| ja |
釘宮, 啓一
宮崎大学
|
| ja-Kana |
クギミヤ, ケイイチ
|
| en |
Kugimiya, Keiichi
University of Miyazaki
|
Search repository
坪内, 拡伸
WEKO
21726
e-Rad_Researcher
60573988
| ja |
坪内, 拡伸
宮崎大学
|
| ja-Kana |
ツボウチ, ヒロノブ
|
| en |
Tsubouchi, Hironobu
University of Miyazaki
|
Search repository
Saito, Kiyotaka
門田, 善仁
WEKO
34651
e-Rad_Researcher
20783088
| ja |
門田, 善仁
宮崎大学
|
| ja-Kana |
カドタ, ヨシヒト
|
| en |
Kadota, Yoshihito
University of Miyazaki
|
Search repository
東, 美菜子
WEKO
34675
e-Rad_Researcher
00643389
| ja |
東, 美菜子
宮崎大学
|
| ja-Kana |
アズマ, ミナコ
|
| en |
Azuma, Minako
University of Miyazaki
|
Search repository
酒井, 克也
WEKO
34802
e-Rad_Researcher
00839491
| ja |
酒井, 克也
宮崎大学
|
| ja-Kana |
サカイ, カツヤ
|
| en |
Sakai, Katsuya
University of Miyazaki
|
Search repository
小田, 康晴
WEKO
34844
e-Rad_Researcher
90843235
| ja |
小田, 康晴
宮崎大学
|
| ja-Kana |
オダ, ヤスハル
|
| en |
Oda, Yasuharu
University of Miyazaki
|
Search repository
住吉, 誠
WEKO
35239
e-Rad_Researcher
60965383
| ja |
住吉, 誠
宮崎大学
|
| ja-Kana |
スミヨシ, マコト
|
| en |
Sumiyoshi, Makoto
University of Miyazaki
|
Search repository
柳, 重久
WEKO
21755
e-Rad_Researcher
60404422
| ja |
柳, 重久
宮崎大学
|
| ja-Kana |
ヤナギ, シゲヒサ
|
| en |
Yanagi, Shigehisa
University of Miyazaki
|
Search repository
宮崎, 泰可
WEKO
34876
| ja |
宮崎, 泰可
宮崎大学
|
| ja-Kana |
ミヤザキ, タイガ
|
| en |
Miyazaki, Taiga
University of Miyazaki
|
Search repository
|
|
内容記述 |
Cerebral radiation necrosis (CRN) is a late complication that can occur after the treatment of a brain tumor with focal radiation therapy, particularly stereotactic radiosurgery (SRS). Since an excessive production of vascular endothelial growth factor (VEGF) from necrotic lesions is a possible etiology of radiation necrosis, the anti-VEGF antibody bevacizumab has been reported as an effective treatment option. We report a case of a 71-year-old Japanese male with CRN following SRS, successfully treated with bevacizumab. He had presented with aphasia and right lower-limb muscle weakness 6 years after a left upper lobectomy for lung adenocarcinoma. Head magnetic resonance imaging (MRI) showed a metastatic brain tumor in the left temporal lobe. A craniotomy and pre- and post-operative SRS treatments were performed to relieve his neurological symptoms. Although initial symptom improvement was observed, the patient developed lower-limb muscle weakness and aphasia symptoms 7 months after the last SRS treatment. 11C-methionine positron emission tomography (PET) and 18F-fluorodeoxyglucose PET scans showed no abnormal uptake, leading to a diagnosis of CRN. The patient was treated with bevacizumab 15 mg/kg every 3 weeks for six cycles. The bevacizumab treatment resulted in an improvement of neurological symptoms and lesions showing gadolinium-enhancing effects and high-signal areas on T2-weighted fluid attenuated inversion recovery on MRI. The improvement was maintained 44 months after the completion of the last bevacizumab treatment. Although no definitive number of cycles and dosage of bevacizumab for CRN have been established, this case suggests that administering six cycles of bevacizumab may prevent long-term recurrence of CRN. |
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