| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-10-07 |
| タイトル |
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|
タイトル |
Outcomes of Resected Cases of Pancreatic Ductal Adenocarcinoma Patients With Unexpected Postoperative Uncovering Noncurative Factors: A Multicenter Retrospective Study |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
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言語 |
en |
|
キーワード |
adjuvant chemotherapy |
| キーワード |
|
|
言語 |
en |
|
キーワード |
frailty |
| キーワード |
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|
言語 |
en |
|
キーワード |
geriatric oncology |
| キーワード |
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|
言語 |
en |
|
キーワード |
pancreatic ductal adenocarcinoma |
| キーワード |
|
|
言語 |
en |
|
キーワード |
radial resection |
| 資源タイプ |
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|
資源タイプ |
journal article |
| アクセス権 |
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|
アクセス権 |
open access |
| 著者 |
Matsui, Hiroto
| en |
Matsui, Hiroto（Personal）
Yamaguchi University Graduate School of Medicine
|
Search repository
Ikenaga, Naoki
Nakamura, Masafumi
Tatsuguchi, Takaaki
| en |
Tatsuguchi, Takaaki（Personal）
Kitakyushu Municipal Medical Center
|
Search repository
Kozono, Shingo
Okabe, Hirohisa
Hayashi, Hiromitsu
Adachi, Tomohiko
Eguchi, Susumu
Hashimoto, Kazuaki
| en |
Hashimoto, Kazuaki（Personal）
Kurume University School of Medicine
|
Search repository
Hisaka, Toru
Ide, Takao
Noshiro, Hirokazu
Hirashita, Teijiro
Miyoshi, Atsushi
七島, 篤志
WEKO
33886
e-Rad_Researcher
60380838
| ja |
七島, 篤志
宮崎大学
|
| ja-Kana |
ナナシマ, アツシ
|
| en |
Nanashima, Atsushi
University of Miyazaki
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Search repository
Kajiwara, Masatoshi
Yoshizumi, Tomoharu
Mori, Yasuhisa
| en |
Mori, Yasuhisa（Personal）
University of Occupational and Environmental Health School of Medicine
|
Search repository
Nagano, Hiroaki
| en |
Nagano, Hiroaki（Personal）
Yamaguchi University Graduate School of Medicine
|
Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Aim
We aimed to refine treatment strategies for resected cases of pancreatic ductal adenocarcinoma in patients with unexpectedly uncovered postoperative noncurative factors while also evaluating the effectiveness of neoadjuvant and adjuvant chemotherapy.
Methods
We retrospectively analyzed clinicopathological and follow-up data from 1068 PDAC patients who underwent surgical resection at 13 Kyushu Study Group institutions (January 2016–December 2020). Patients were categorized into two groups: without (Group A) or with (Group B) unexpected postoperative noncurative factors. Kaplan–Meier analysis assessed disease-free and overall survival, while univariate and multivariate analyses using the Cox proportional hazards model identified prognostic factors.
Results
Group B (n = 44) had poorer survival than Group A (n = 981) (16.8 vs. 38.6 months; p < 0.001). The noncurative factors were associated with poor disease-free survival (hazard ratio, 1.544; 95% confidence interval, 1.067–2.179; p = 0.022) but not overall survival (hazard ratio, 1.332; 95% confidence interval, 0.910–1.950; p = 0.140). In Group B, patients receiving adjuvant chemotherapy had better disease-free survival (6.8 months vs. 3.4 months; p = 0.092), However, no significant difference was observed in overall survival. Furthermore, patients in Group B who received adjuvant chemotherapy had a worse prognosis compared to both Group A patients who received chemotherapy and those who did not. Preoperative therapy did not improve disease-free survival or overall survival in cases with postoperative noncurative factors.
Conclusion
Cases with noncurative factors had significantly poorer prognoses than those without. In the present study, effective adjuvant chemotherapy for these patients could not be demonstrated. Therefore, thorough preoperative and intraoperative evaluation of noncurative factors is crucial to prevent futile surgery. |
|
言語 |
en |
| 書誌情報 |
en : Annals of Gastroenterological Surgery
発行日 2025-09-09
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| 出版者 |
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出版者 |
Wiley |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
24750328 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1002/ags3.70090 |
| 著者版フラグ |
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出版タイプ |
VoR |
fulltext (536 KB)
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