| 著者 |
Hashimoto, Yoshinori
| en |
Hashimoto, Yoshinori（Personal）
Tottori Prefectural Central Hospital
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Search repository
Ito, Tomoki
Gotoh, Akihiko
Nakamae, Mika
Kimura, Fumihiko
Koike, Michiaki
Kirito, Keita
Wada, Hideho
Usuki, Kensuke
Tanaka, Takayuki
Mori, Takehiko
Wakita, Satoshi
| en |
Wakita, Satoshi（Personal）
Department of Hematology Nippon Medical School Bunkyo City Tokyo Japan.
|
Search repository
Saito, Toshiki I
| en |
Saito, Toshiki I（Personal）
Clinical Research Center NHO Nagoya Medical Center Nagoya Aichi Japan.
|
Search repository
Kada, Akiko
| en |
Kada, Akiko（Personal）
Clinical Research Center NHO Nagoya Medical Center Nagoya Aichi Japan.
|
Search repository
Saito, Akiko M
| en |
Saito, Akiko M（Personal）
Clinical Research Center NHO Nagoya Medical Center Nagoya Aichi Japan.
|
Search repository
下田, 和哉
WEKO
7997
e-Rad_Researcher
90311844
| en |
Shimoda, Kazuya
University of Miyazaki
|
| ja |
下田, 和哉
宮崎大学
|
| ja-Kana |
シモダ, カズヤ
|
Search repository
Sugimoto, Yuka
Kurokawa, Toshiro
Tomita, Akihiro
| en |
Tomita, Akihiro（Personal）
Fujita Health University School of Medicine
|
Search repository
Edahiro, Yoko
Kiyoi, Hitoshi
Akashi, Koichi
Matsumura, Itaru
Takenaka, Katsuto
Komatsu, Norio
|
|
内容記述 |
Objectives
The present study investigated the effects of thrombosis, hemorrhagic events, disease progression, and secondary malignancies on patient survival after the diagnosis of essential thrombocythemia (ET).
Methods
We analyzed data from 1152 patients enrolled in the JSH-MPN-18 study using time-dependent Cox regression and multistate Markov models to estimate transition hazards and state occupation probabilities.
Results
Hemorrhagic events (hazard ratio = 2.92, 95% confidence interval = 1.78–4.78, p < 0.001) was associated with a poor prognosis. In multistate model, hazards from the hemorrhagic event to death were higher among cumulative transition hazards, and the probability of remaining in the hemorrhagic state was lower than the probability of remaining in the other states of thrombosis, disease progression, and secondary malignancy in state occupancy probabilities.
Conclusions
The present results demonstrated that hemorrhagic events following the diagnosis of ET are a serious risk factor and are directly related to early death. Baseline characteristics and post-diagnosis events (intermediate status) may both have a significant impact on survival, and treatment strategies that take into account the prevention of an intermediate status need to be incorporated into clinical practice.
Trial Registration
The authors have confirmed clinical trial registration is not needed for this submission. |
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