| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-10-06 |
| タイトル |
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タイトル |
Targeted Screening with the Use of Clinical Risk Factors for Detecting Congenital Cytomegalovirus Infection in Newborns: A Prospective Multicenter Cohort Study |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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|
言語 |
en |
|
キーワード |
congenital infection |
| キーワード |
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言語 |
en |
|
キーワード |
cytomegalovirus |
| キーワード |
|
|
言語 |
en |
|
キーワード |
newborn |
| キーワード |
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言語 |
en |
|
キーワード |
screening |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Kataoka, Soromon
金子, 政時
WEKO
24696
e-Rad_Researcher
40264387
| ja |
金子, 政時
宮崎大学
|
| ja-Kana |
カネコ, マサトキ
|
| en |
Kaneko, Masatoki
University of Miyazaki
|
Search repository
Yang, Li
Ota, Hajime
Seki, Moeka
Kobamatsu, Aya
Nakayama, Daiki
Furuta, Yu
Tanuma, Fumie
Fukushi, Yoshiyuki
Wada, Shinichiro
Haseyama, Keiji
Yamada, Hideto
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Congenital cytomegalovirus infection (cCMV) is one of the most common congenital infections. This study aimed to evaluate the diagnostic performance of targeted screening with the use of clinical risk factors for cCMV. A total of 3063 pregnant women and their 3139 newborns were enrolled. Six clinical findings consisting of maternal fever or flu-like symptoms during pregnancy (fever/flu-like symptoms), hospitalization for threatened miscarriage or preterm labor before 34 weeks of gestation, preterm delivery before 34 weeks of gestation, fetal ultrasound abnormalities, small for gestational age (SGA), and refer results of automated auditory brainstem response screening (AABR refer) were defined as cCMV risk factors before participant registration. All newborns underwent urine cytomegalovirus polymerase chain reaction tests within one week of birth. The predictive accuracy of these six risk factors was analyzed. Nine (0.29%) of the three thousand one hundred and thirty-nine newborns were diagnosed with cCMV, having at least one of the six risk factors. Logistic regression analysis identified fever/flu-like symptoms (odds ratio (OR), 7.5; 95% CI, 1.9-30.3), fetal ultrasound abnormalities (OR, 17.9; 95% CI, 4.4-72.8), SGA (OR, 6.8; 95% CI, 1.8-25.6), and AABR refer (OR, 75.5; 95% CI, 19.7-289) as significant risk factors. The predictive accuracy of the targeted screening for cCMV, when at least one of the six risk factors was present, yielded 100% sensitivity (95% CI, 55.5-100) and 70.7% specificity (95% CI, 69.1-72.3), with a Youden index of 0.707. When at least one of the four significant risk factors was present, 100% sensitivity (95% CI, 55.5-100) and 81.2% specificity (95% CI, 79.8-82.6) with the maximum Youden index of 0.812 were achieved. In conclusion, targeted screening with the use of clinical risk factors in mothers and their newborns could effectively identify cCMV. |
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言語 |
en |
| 書誌情報 |
en : Microorganisms
巻 13,
号 9,
p. 2197,
発行日 2025-09-19
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| 出版者 |
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出版者 |
MDPI AG |
|
言語 |
en |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
20762607 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3390/microorganisms13092197 |
| 著者版フラグ |
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出版タイプ |
VoR |
fulltext (401 KB)
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