| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-08-27 |
| タイトル |
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タイトル |
Synergic Treatment of Plant-Based Antioxidants with Iron Chelators for Iron Overload in Transfusion-Dependent-Thalassemia Patients: A Systematic Review |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
Plant-based antioxidant |
| キーワード |
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言語 |
en |
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キーワード |
Supplement |
| キーワード |
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言語 |
en |
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キーワード |
Transfusion-dependent thalassemia |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Kyaw, Moe Thida
ピュー , シン ウー
WEKO
27789
e-Rad_Researcher
90718123
| ja |
ピュー , シン ウー
宮崎大学
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| ja-Kana |
ピュー , シン ウー
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| en |
Phyu, Synn Oo
University of Miyazaki
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Search repository
Sumera, Afshan
Sivakumar, Anupa
Santiago, Carolina
Aung, Yin Nwe
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The combined use of plant-based antioxidants and iron chelators presents a synergistic treatment approach that effectively tackles both iron overload and the accompanying oxidative stress in individuals with transfusion-dependent Thalassemia (TDT). Plant-based antioxidants counteract reactive oxygen species (ROS) and oxidative damage, whereas iron chelators effectively bind excess iron, reducing the body's iron concentration. This combined therapy can be beneficial in improving TDT patients with iron overload. We systematically reviewed the literature exploring the plant-based antioxidants with iron chelators for iron overload in transfusion-dependent Thalassemia Patients. All fourteen included studies were randomized clinical trials, employing various randomization methods including simple randomization, double-blinded, triple-blinded, and crossover designs. The included studies enrolled participants across different age groups, including both young and adult patients. Despite the variability in plant-based antioxidants with iron-chelating properties, the key findings were as follows: Nine studies reported a significant reduction in iron overload, eight studies observed a marked decrease in oxidative stress markers, and five studies demonstrated reduced liver enzyme levels, suggesting potential hepatoprotective effects. All included studies reported significant effects of various supplements on key biomarkers, including total iron (Fe), ferritin, total iron-binding capacity (TIBC), total antioxidant capacity (TAC), malondialdehyde (MDA), and liver enzymes (AST, ALT). Silymarin, green tea, and grape seed extract (GSE) supplementation demonstrated notable reductions in total Fe, Ferritin, ASL, and ALT levels. Additionally, these supplements increased TIBC levels, suggesting improved iron metabolism. In contrast, quercetin and curcumin supplementation did not show a statistically significant difference compared to control groups in these outcomes. |
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言語 |
en |
| 書誌情報 |
en : International Journal of Hematology Oncology and Stem Cell Research
巻 19,
号 3,
p. 261-285,
発行日 2025-08-01
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| 出版者 |
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出版者 |
Tehran University of Medical Sciences. |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
20082207 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
17351243 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.18502/ijhoscr.v19i3.19289 |
| 権利 |
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権利情報 |
© 2025 Tehran University of Medical Sciences. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
Fulltext (789 KB)
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