| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-08-27 |
| タイトル |
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タイトル |
Local Therapy Can Enhance the Prognosis of Certain Patients with Pathologically Diagnosed Neuroendocrine Prostate Carcinoma |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
local therapy |
| キーワード |
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言語 |
en |
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キーワード |
neuroendocrine prostate carcinoma |
| キーワード |
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言語 |
en |
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キーワード |
prostate cancer |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
木村, 翔一
WEKO
35124
| ja |
木村, 翔一
宮崎大学
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| ja-Kana |
キムラ, ショウイチ
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| en |
Kimura, Syoichi
Kimura, Shoichi
University of Miyazaki
|
Search repository
Terada, Naoki
Soumiya, Shinnya
Goto, Takayuki
Negoro, Hiromitsu
向井, 尚一郎
WEKO
26958
| en |
Mukai, Shoichiro
University of Miyazaki
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| ja |
向井, 尚一郎
宮崎大学
|
| ja-Kana |
ムカイ, ショウイチロウ
|
Search repository
Ogawa, Osamu
Akamatsu, Shusuke
Kobayashi, Takashi
澤田, 篤郎
WEKO
35206
e-Rad_Researcher
10784796
| ja |
澤田, 篤郎
宮崎大学
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| ja-Kana |
サワダ, アツロウ
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| en |
Sawada, Atsuro
University of Miyazaki
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Search repository
賀本, 敏行
WEKO
9783
e-Rad_Researcher
00281098
| ja |
賀本, 敏行
宮崎大学
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| ja-Kana |
カモト, トシユキ
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| en |
Kamoto, Toshiyuki
University of Miyazaki
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Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Neuroendocrine prostate cancer (NEPC) has a poor prognosis. We performed a retrospective analysis of the factors contributing to survival in patients with histologically diagnosed NEPC. Patients pathologically diagnosed with NEPC between 2007 and 2018 were retrospectively analyzed. Overall survival (OS) from the time of the initial prostate cancer diagnosis was evaluated using the Kaplan–Meier method. Cox proportional hazards analyses were performed to evaluate the association of OS with variables including the presence of metastasis, receipt of local therapy, and disease classification (primary NEPC [p-NEPC] or treatment-related NEPC [t-NEPC]). Among 32 patients (p-NEPC, 22; t-NEPC, 10), distant metastases were identified in 25 (78%) patients, and local therapies including radical prostatectomy and local radiotherapy were provided to 21 (66%) patients. In the univariate Cox proportional hazard analyses, patients who received local therapy had a significantly lower risk of death than those who did not receive local therapy (hazard ratio = 0.284, 95% confidence interval = 0.109–0.738, p = 0.01). OS was significantly longer for patients receiving local therapy than for those who did not receive local therapy (36 months vs. 13 months, p = 0.0058). Our findings suggest the potential benefit of local therapy in the treatment of NEPC. |
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言語 |
en |
| 書誌情報 |
en : Life
巻 15,
号 5,
p. 797,
発行日 2025-05-17
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| 出版者 |
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出版者 |
MDPI |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
20751729 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3390/life15050797 |
| 権利 |
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権利情報 |
© 2025 by the authors. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
Fulltext (786 KB)
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