| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-08-27 |
| タイトル |
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タイトル |
Whole-Genome Sequencing and Comparative Genomic Analysis of Three Clinical Bloodstream Infection Isolates of Trichosporon austroamericanum |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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|
言語 |
en |
|
キーワード |
bloodstream infections |
| キーワード |
|
|
言語 |
en |
|
キーワード |
comparative genomics |
| キーワード |
|
|
言語 |
en |
|
キーワード |
Galleria mellonella |
| キーワード |
|
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言語 |
en |
|
キーワード |
ortholog analysis |
| キーワード |
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|
言語 |
en |
|
キーワード |
pathogenicity |
| キーワード |
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|
言語 |
en |
|
キーワード |
Trichosporon austroamericanum |
| キーワード |
|
|
言語 |
en |
|
キーワード |
whole-genome sequencing |
| キーワード |
|
|
言語 |
en |
|
キーワード |
zinc cluster transcription factor |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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|
アクセス権 |
open access |
| 著者 |
堀口, 崇典
WEKO
35416
| ja |
堀口, 崇典
宮崎大学
|
| ja-Kana |
ホリグチ, タカノリ
|
| en |
Horiguchi, Takanori
University of Miyazaki
|
Search repository
Umeyama, Takashi
Tomuro, Hiroko
Otani, Amato
Shinohara, Takayuki
Abe, Masahiro
Takatsuka, Shogo
Miyazawa, Ken
Nagi, Minoru
Muraosa, Yasunori
Hoshino, Yasutaka
Sakoh, Takashi
Araoka, Hideki
Uchida, Naoyuki
Kaneko, Tomoyoshi
Nagano, Yuko
Tsukada, Hiroki
宮崎, 泰可
WEKO
34876
| ja |
宮崎, 泰可
宮崎大学
|
| ja-Kana |
ミヤザキ, タイガ
|
| en |
Miyazaki, Taiga
University of Miyazaki
|
Search repository
Miyazaki, Yoshitsugu
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Trichosporon austroamericanum is a recently described yeast species related to Trichosporon inkin and exclusively isolated from clinical specimens. However, its genomic features and pathogenic potential remain poorly understood. In this study, we performed whole-genome sequencing on three blood-derived isolates from patients with invasive fungal infections and comparative analyses with 13 related Trichosporon species. The three isolates yielded high-quality assemblies of 9–10 scaffolds (~21 Mb), facilitating reliable comparisons. While most species had comparable genome sizes, Trichosporon ovoides, Trichosporon coremiiforme, and Cutaneotrichosporon mucoides displayed large, fragmented genomes, suggestive of polyploidy. ANI analysis and phylogenetic trees based on ANI and single-copy orthologs supported the classification of T. austroamericanum as a distinct clade with moderate intraspecific divergence. Using the Galleria mellonella, a model for fungal pathogenicity, all T. austroamericanum strains reduced larval survival, and NIIDF 0077300 exhibited virulence comparable to T. asahii and greater than T. inkin. To explore the gene-level differences associated with pathogenicity, we performed ortholog analysis based on single-copy genes. This revealed a unique Zn(II)2Cys6-type transcription factor gene (OG0010545) present only in NIIDF 0077300 and T. asahii. These findings highlight the genomic diversity and infection-associated traits of T. austroamericanum, providing a framework for future functional studies. |
|
言語 |
en |
| 書誌情報 |
en : Journal of Fungi
巻 11,
号 5,
p. 401,
発行日 2025-04-18
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| 出版者 |
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出版者 |
MDPI |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2309608X |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3390/jof11050401 |
| 権利 |
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|
権利情報 |
© 2025 by the authors. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
Fulltext (1.6 MB)
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