| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-08-27 |
| タイトル |
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タイトル |
Risk Factors and Long-Term Prognosis for Coinfection of Nontuberculous Mycobacterial Pulmonary Disease and Chronic Pulmonary Aspergillosis: A Multicentre Observational Study in Japan |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
Aspergillus |
| キーワード |
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言語 |
en |
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キーワード |
coinfection |
| キーワード |
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言語 |
en |
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キーワード |
Mycobacterium avium complex |
| キーワード |
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言語 |
en |
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キーワード |
Mycobacterium infections |
| キーワード |
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言語 |
en |
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キーワード |
nontuberculous mycobacteria |
| キーワード |
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言語 |
en |
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キーワード |
propensity score |
| キーワード |
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言語 |
en |
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キーワード |
pulmonary aspergillosis |
| キーワード |
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言語 |
en |
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キーワード |
retrospective studies |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Tanaka, Yasuhiro
Ide, Shotaro
Takazono, Takahiro
Takeda, Kazuaki
Iwanaga, Naoki
Yoshida, Masataka
Hosogaya, Naoki
Tsukamoto, Yusei
Irifune, Satoshi
Suyama, Takayuki
Mihara, Tomo
| en |
Mihara, Tomo
Japan Community Health care Organization Isahaya General Hospital
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Search repository
Kondo, Akira
| en |
Kondo, Akira
National Hospital Organization Nagasaki Medical Center
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Search repository
Kobayashi, Tsutomu
Fukuda, Yuichi
Sasaki, Eisuke
| en |
Sasaki, Eisuke
National Hospital Organization Ureshino Medical Center
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Search repository
Sawai, Toyomitsu
Higashiyama, Yasuhito
Hashiguchi, Kohji
Hanaka, Minako
Ii, Toshihiko
| en |
Ii, Toshihiko
National Hospital Organization Miyazaki-Higashi National Hospital
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Search repository
Fukushima, Kiyoyasu
| en |
Fukushima, Kiyoyasu
Japanese Red Cross Nagasaki Genbaku Isahaya Hospital
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Search repository
Komiya, Kosaku
宮崎, 泰可
WEKO
34876
| ja |
宮崎, 泰可
宮崎大学
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| ja-Kana |
ミヤザキ, タイガ
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| en |
Miyazaki, Taiga
University of Miyazaki
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Search repository
Yatera, Kazuhiro
| en |
Yatera, Kazuhiro
University of Occupational and Environmental Health, Japan
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Search repository
Izumikawa, Koichi
Furumoto, Akitsugu
Yanagihara, Katsunori
Mukae, Hiroshi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background
Nontuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic respiratory infection with increasing prevalence and mortality worldwide. Coinfection with chronic pulmonary aspergillosis (CPA) is a significant complication of NTM-PD, often complicating treatment and resulting in poor prognosis.
Objective
In this multicentre, retrospective cohort study, we examined the epidemiology, comorbidities, risk factors for CPA coinfection and long-term prognosis of patients with NTM-PD infected with CPA in Japan.
Methods
Patients aged ≥ 18 years with newly diagnosed NTM-PD who visited 18 hospitals between 2010 and 2017 in Kyushu, Japan, were included. Medical records were reviewed for patient characteristics, mycobacterial species, laboratory data, radiological features, Aspergillus coinfection and all-cause mortality rates. Risk factors for CPA coinfection were analysed using multiple logistic regression, and survival analysis was performed before and after propensity score matching with risk factors.
Results
Among 1304 patients with NTM-PD, 45 (3.5%) were diagnosed with CPA, including 42 with chronic progressive pulmonary aspergillosis. The risk factors for CPA coinfection included male sex, chronic obstructive pulmonary disease, oral corticosteroid use and cavity formation. All-cause mortality was significantly higher in patients with NTM-PD with CPA than in those without CPA (log-rank test, p < 0.001; crude hazard ratio [HR], 3.98). Survival analysis after propensity score matching suggested CPA was an independent poor prognostic factor (log-rank test, p = 0.036; adjusted HR, 1.59).
Conclusion
CPA is an independent poor prognostic factor in patients with NTM-PD. Clinicians must consider CPA when treating patients with NTM-PD, particularly those with high-risk factors, to ensure timely diagnosis and management. |
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言語 |
en |
| 書誌情報 |
en : Mycoses
巻 68,
号 6,
p. e70083,
発行日 2025-06-19
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| 出版者 |
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出版者 |
Wiley |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
14390507 |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
09337407 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1111/myc.70083 |
| 権利 |
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権利情報 |
© 2025 The Author(s). |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
Fulltext (447 KB)
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